{"id":"W3199172657","doi":"10.26434/chemrxiv.7119887.v1","title":"Catalytic Enantioselective Benzylation Directly from Aryl Acetic Acids","year":2018,"lang":"en","type":"preprint","venue":"ChemRxiv","topic":"Catalytic C–H Functionalization Methods","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Enantioselective synthesis; Decarboxylation; Chemistry; Electrophile; Nucleophile; Carbanion; Allylic rearrangement; Aryl; Combinatorial chemistry; Reactive intermediate; Catalysis; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003783753,0.0006302292,0.0006809877,0.0001681175,0.0001731659,0.0001684004,0.0006311829,0.000931116,0.006023736],"category_scores_gemma":[0.00115289,0.0006955254,0.0003512604,0.0003339761,0.0002481035,0.0001353519,0.0007481203,0.0008841923,0.0005770921],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006907595,"about_ca_system_score_gemma":0.0005004997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003114422,"about_ca_topic_score_gemma":0.00003989378,"domain_scores_codex":[0.996787,0.00003890306,0.0007056088,0.001391152,0.0006261441,0.0004512438],"domain_scores_gemma":[0.9966902,0.0004967782,0.0005831726,0.001518486,0.0005039381,0.0002073875],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004550893,0.0008024043,0.0330049,0.002061356,0.002505834,0.0000479217,0.003237213,0.001004637,0.9017107,0.0005745549,0.03894769,0.01564773],"study_design_scores_gemma":[0.0006797014,0.00001209616,0.004632456,0.000407658,0.0004485127,0.00001010543,0.0000582536,0.003967064,0.9656737,0.01279478,0.01038262,0.0009330116],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9021981,0.001295411,0.0268571,0.0004043917,0.002929769,0.000503549,0.0003117631,0.001060239,0.06443971],"genre_scores_gemma":[0.9719051,0.00009788302,0.005775528,0.0001342839,0.003685672,0.0002246198,0.008274837,0.0002127795,0.009689257],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06970707,"threshold_uncertainty_score":0.9995496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02683880920974552,"score_gpt":0.287377902327574,"score_spread":0.2605390931178285,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}