{"id":"W3199174046","doi":"10.1096/fj.202100038rr","title":"Gelsolin is an important mediator of Angiotensin II‐induced activation of cardiac fibroblasts and fibrosis","year":2021,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Cardiac Fibrosis and Remodeling","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Periostin; Cardiac fibrosis; Gelsolin; Angiotensin II; Fibrosis; Myocardial fibrosis; Fibronectin; Myofibroblast; Chemistry; Actin; Cell biology; PI3K/AKT/mTOR pathway; Extracellular matrix; Internal medicine; Endocrinology; Signal transduction; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001323998,0.0003520467,0.000148374,0.0003363885,0.0001847243,0.0002376278,0.00008462596,0.0002356401,0.00114842],"category_scores_gemma":[0.00007343943,0.0001345968,0.0002645149,0.0001161294,0.0001930911,0.0001627152,0.0001903365,0.0004065543,0.0002170981],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000248977,"about_ca_system_score_gemma":0.0001188209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002645058,"about_ca_topic_score_gemma":0.0004016951,"domain_scores_codex":[0.9998915,0.00002267767,0.000009898678,0.00002427077,0.00002722611,0.00002443555],"domain_scores_gemma":[0.9998968,0.000009574473,0.00003815181,0.000004870609,0.0000112535,0.0000394092],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001817697,0.00001786104,0.0004228747,0.0000847146,0.00000808591,0.0001448585,0.00001287936,0.0000171708,0.9979509,0.00008698605,0.00006268334,0.001009285],"study_design_scores_gemma":[0.00005694825,0.0004138474,0.04737984,0.00003804883,0.00004517441,0.001615094,0.00008887096,0.0007350275,0.9415893,0.0002802839,0.007742635,0.00001499214],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9739109,0.01654912,0.003984127,0.0004235087,0.0001737381,0.00006119866,0.000685759,0.0001291038,0.004082612],"genre_scores_gemma":[0.9928773,0.002299266,0.001550842,0.0001140393,0.00003931715,0.00004799043,0.0004311829,0.00001183951,0.002628152],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00114842,"threshold_uncertainty_score":0.003841877,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02212549805104213,"score_gpt":0.2628123691593306,"score_spread":0.2406868711082885,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}