{"id":"W3199184757","doi":"10.1038/s41418-021-00894-w","title":"Bcl-xL acts as an inhibitor of IP3R channels, thereby antagonizing Ca2+-driven apoptosis","year":2021,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"National Institute of Dental and Craniofacial Research; Vlaamse regering; Onderzoeksraad, KU Leuven; Canadian Institutes of Health Research; KU Leuven; Fonds Wetenschappelijk Onderzoek; National Institutes of Health; Vlaams Instituut voor Biotechnologie; U.S. Department of Health and Human Services; Government of Canada; Belgian Federal Science Policy Office","keywords":"Bcl-xL; Staurosporine; Apoptosis; Cell biology; Endoplasmic reticulum; Bcl-2 family; Receptor; Programmed cell death; HeLa; Chemistry; Biology; Molecular biology; Kinase; Cell; Biochemistry; Protein kinase A","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001653933,0.0003559339,0.000230075,0.0001813174,0.000156564,0.0002820177,0.000285368,0.000193594,0.001659386],"category_scores_gemma":[0.0001347976,0.0001116367,0.0002329303,0.0001439145,0.0002172549,0.0002122234,0.0001396807,0.0006054403,0.0004399551],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002668412,"about_ca_system_score_gemma":0.0001681088,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002410185,"about_ca_topic_score_gemma":0.0002635575,"domain_scores_codex":[0.9998802,0.00002138172,0.00001612735,0.00001824228,0.00003102808,0.00003313504],"domain_scores_gemma":[0.999854,0.00003677127,0.00003533861,0.00002288835,0.00001578415,0.00003528456],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001248334,0.000041363,0.0001391262,0.00002370421,0.000007848028,0.00003089016,0.000005160152,0.00009744341,0.9983047,0.0001232595,0.00005562849,0.001045996],"study_design_scores_gemma":[0.00004122142,0.0002497971,0.0008293309,0.00000262402,0.00001159822,0.0001208687,0.000005316887,0.001555209,0.9956952,0.00003081253,0.001455956,0.000002025212],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900739,0.001209096,0.005821071,0.0001658969,0.00005880803,0.00003524626,0.0003118876,0.00026503,0.002059059],"genre_scores_gemma":[0.995901,0.0003890748,0.00208816,0.0000607012,0.00001143643,0.0000247638,0.0003005783,0.00002022956,0.001203902],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001659386,"threshold_uncertainty_score":0.005551219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01102826198260555,"score_gpt":0.2263286756719971,"score_spread":0.2153004136893916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}