{"id":"W3199184757","doi":"10.1038/s41418-021-00894-w","title":"Bcl-xL acts as an inhibitor of IP3R channels, thereby antagonizing Ca2+-driven apoptosis","year":2021,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"National Institute of Dental and Craniofacial Research; Vlaamse regering; Onderzoeksraad, KU Leuven; Canadian Institutes of Health Research; KU Leuven; Fonds Wetenschappelijk Onderzoek; National Institutes of Health; Vlaams Instituut voor Biotechnologie; U.S. Department of Health and Human Services; Government of Canada; Belgian Federal Science Policy Office","keywords":"Bcl-xL; Staurosporine; Apoptosis; Cell biology; Endoplasmic reticulum; Bcl-2 family; Receptor; Programmed cell death; HeLa; Chemistry; Biology; Molecular biology; Kinase; Cell; Biochemistry; Protein kinase A","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000555984,0.0001385535,0.0001470823,0.0000389435,0.00009275647,0.00004220608,0.00005575455,0.0001712041,0.00004296187],"category_scores_gemma":[0.00001579865,0.0001284111,0.00006473528,0.00005807569,0.0000175694,0.00001217702,0.00006609241,0.00004861697,0.00000264403],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008430765,"about_ca_system_score_gemma":0.00004398062,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002005488,"about_ca_topic_score_gemma":0.00001453638,"domain_scores_codex":[0.9991663,0.00005551453,0.0001825067,0.0003165203,0.0001175839,0.0001616225],"domain_scores_gemma":[0.9994628,0.000006508935,0.0001092239,0.0002146145,0.0001088157,0.00009800106],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003437915,0.0001243448,0.00180114,0.00005362498,0.00001975436,9.147688e-7,0.0001434606,0.00003554826,0.993807,0.0004961655,0.00003106524,0.003452589],"study_design_scores_gemma":[0.000613776,0.0002092504,0.006768194,0.00002079837,0.0000462325,0.000005049631,0.000166362,0.001149423,0.9894023,0.0003801502,0.001077359,0.0001611206],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950196,0.0007989933,0.003086774,0.00003127637,0.0002962366,0.0001190665,0.00001082436,0.00001099948,0.0006262846],"genre_scores_gemma":[0.9966764,0.001028531,0.0004227974,0.00005106134,0.0002338282,0.000006866346,0.0007988124,0.00001883994,0.0007627928],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004967054,"threshold_uncertainty_score":0.5236452,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01102826198260555,"score_gpt":0.2263286756719971,"score_spread":0.2153004136893916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}