{"id":"W3199216558","doi":"10.3389/fonc.2021.742949","title":"The Role of Cellular Prion Protein in Cancer Biology: A Potential Therapeutic Target","year":2021,"lang":"en","type":"review","venue":"Frontiers in Oncology","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; CancerCare Manitoba","funders":"National Natural Science Foundation of China","keywords":"Prion protein; Gene isoform; Biology; Scrapie; Cancer; Cancer cell; Metastasis; Cell biology; Cancer research; Disease; Medicine; Pathology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002695514,0.0005162056,0.000806054,0.001421152,0.0002239209,0.0006893629,0.0004485793,0.0008157304,0.003132981],"category_scores_gemma":[0.0002797809,0.0001558815,0.0002911699,0.001218444,0.000295873,0.0009316164,0.0004714866,0.001302056,0.0017821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004409327,"about_ca_system_score_gemma":0.0006189322,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004917743,"about_ca_topic_score_gemma":0.001004351,"domain_scores_codex":[0.9999232,0.00001423044,0.000008650209,0.00001264568,0.00003014656,0.00001100842],"domain_scores_gemma":[0.9998811,0.00005286589,0.00001341476,0.000003903556,0.0000338534,0.00001478015],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000698949,0.00007441507,0.0001402972,0.01312536,0.00005188123,0.0003580634,0.0000774874,0.000354602,0.005965019,0.005824326,0.03297039,0.9409884],"study_design_scores_gemma":[0.00001071066,0.00008983613,0.000409639,0.001565337,0.00004861887,0.001402138,0.00004169779,0.00007231483,0.0007818616,0.001928613,0.9936381,0.000011094],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001902622,0.9978276,0.0001450386,0.0003382491,0.0001777526,0.000004010441,0.00001864446,0.000008336392,0.001289995],"genre_scores_gemma":[0.0008664123,0.9979582,0.0001616053,0.0001646712,0.0001195883,0.000005354381,0.00003079888,0.000001253427,0.0006920423],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003132981,"threshold_uncertainty_score":0.01048082,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01365522004152758,"score_gpt":0.3239196547172142,"score_spread":0.3102644346756866,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}