{"id":"W3199235790","doi":"10.1101/2021.09.10.457789","title":"Induction of transposable element expression is central to innate sensing","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Labex Immuno-Oncology; Institut Universitaire de France; Ligue Contre le Cancer; Fondation pour la Recherche Médicale; Institut National Du Cancer; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; Université de Paris; Association pour la Recherche sur le Cancer; Seerave Foundation; Institut Gustave-Roussy; Fondation Leducq; European Commission; Centre National de la Recherche Scientifique; Equipex; Danish Cancer Society Research Center","keywords":"Innate immune system; Biology; Cell biology; Transposable element; Histone; Epigenetics; TLR3; Endogeny; DNA; Genome; Immune system; Genetics; Gene; Toll-like receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001321419,0.0002229825,0.0001718782,0.0001395361,0.0001323764,0.0003584623,0.0001362672,0.000264927,0.002803928],"category_scores_gemma":[0.0001291799,0.0001004528,0.0001832554,0.00009666351,0.0002648874,0.0001774488,0.0002605844,0.0004844617,0.001186661],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002617245,"about_ca_system_score_gemma":0.0001947299,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001601055,"about_ca_topic_score_gemma":0.0001567982,"domain_scores_codex":[0.9998608,0.00001607834,0.000008660852,0.00004308643,0.00004415209,0.00002723269],"domain_scores_gemma":[0.9999169,0.00001006126,0.00002234825,0.00001853868,0.00001177769,0.0000204431],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000036489,0.000006056328,0.0003355519,0.00002852434,0.000002682235,0.0000487022,0.00001010733,0.00003043491,0.9971368,0.0004672162,0.00008309686,0.001814263],"study_design_scores_gemma":[0.00001092131,0.0001138153,0.007634659,0.00001198145,0.000009976663,0.0004041578,0.00003817799,0.0009479321,0.9803729,0.0008929746,0.009558025,0.000004479944],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.961069,0.004898848,0.0197759,0.0008330436,0.0002672124,0.00004084332,0.00105755,0.0006925129,0.01136518],"genre_scores_gemma":[0.984144,0.001390944,0.003991226,0.0001163481,0.00006899887,0.00001992809,0.0007443159,0.00004872938,0.009475518],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002803928,"threshold_uncertainty_score":0.009380043,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0134255864874772,"score_gpt":0.2232170932258479,"score_spread":0.2097915067383707,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}