{"id":"W3199261034","doi":"10.1016/j.jmb.2021.167244","title":"HIF-1α Hydroxyprolines Modulate Oxygen-Dependent Protein Stability Via Single VHL Interface With Comparable Effect on Ubiquitination Rate","year":2021,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Ubiquitin ligase; Hydroxylation; Ubiquitin; Protein subunit; Hypoxia-inducible factors; Chemistry; Hydroxyproline; Proline; Oxygen tension; Biochemistry; DNA ligase; Cell biology; Oxygen; Biophysics; Biology; Amino acid; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001174235,0.0001392345,0.0001499239,0.00007599087,0.0001525701,0.0002609768,0.0001763547,0.0001744681,0.001505979],"category_scores_gemma":[0.0001680333,0.00007558412,0.0001676238,0.00006526412,0.0001387844,0.0002397527,0.000153,0.0003265575,0.0002455181],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002904639,"about_ca_system_score_gemma":0.0001125559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003700901,"about_ca_topic_score_gemma":0.000511813,"domain_scores_codex":[0.9998957,0.00001422236,0.000007854615,0.00003005233,0.00001932647,0.00003287214],"domain_scores_gemma":[0.9998888,0.00001665893,0.00003411026,0.00001393428,0.00001541632,0.00003109212],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003827132,0.00002879218,0.0002200122,0.00001801561,0.000004942141,0.00001671674,0.00001122949,0.0000493756,0.9981646,0.00006874882,0.00003440371,0.001000534],"study_design_scores_gemma":[0.00001911126,0.0001312195,0.001608632,0.000002015996,0.000008144805,0.00006451818,0.00001229516,0.0006110047,0.996776,0.0000261961,0.0007373202,0.00000342922],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978903,0.0005390963,0.0009108753,0.0000415475,0.00002191831,0.000006410725,0.00008184352,0.0000321147,0.0004759725],"genre_scores_gemma":[0.9985024,0.0001335445,0.0003764378,0.00002573391,0.00000486514,0.000004771157,0.00009418245,0.00001053291,0.0008474812],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001505979,"threshold_uncertainty_score":0.005037963,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009476928618769578,"score_gpt":0.2589434993431398,"score_spread":0.2494665707243702,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}