{"id":"W3199383294","doi":"10.1161/circ.132.suppl_3.12450","title":"Abstract 12450: Long-Term Efficacy and Safety of Lomitapide for the Treatment of Homozygous Familial Hypercholesterolemia: Results of the Phase 3 Extension Trial","year":2015,"lang":"en","type":"article","venue":"Circulation","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Chicoutimi; Robarts Clinical Trials","funders":"","keywords":"Medicine; Familial hypercholesterolemia; Adverse effect; Internal medicine; Apheresis; Surgery; Gastroenterology; Cholesterol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0026902,0.001155748,0.001330278,0.0002155631,0.0004067086,0.0008563579,0.0005295903,0.00112502,0.003146201],"category_scores_gemma":[0.001654994,0.000273392,0.001246057,0.0002028745,0.0005320208,0.0006798115,0.0002331261,0.002765375,0.0008465774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004252292,"about_ca_system_score_gemma":0.0008671779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004095386,"about_ca_topic_score_gemma":0.0007296643,"domain_scores_codex":[0.9994815,0.0002847985,0.00003585052,0.00005456769,0.00006499502,0.00007826292],"domain_scores_gemma":[0.9986988,0.000337753,0.0003066358,0.0001086288,0.0001355343,0.0004125909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8379957,0.0263289,0.007816372,0.0007772801,0.002209753,0.0004118324,0.0003027877,0.001111465,0.03841489,0.0002009927,0.008709284,0.07572068],"study_design_scores_gemma":[0.7168476,0.2459977,0.02761671,0.00006825681,0.001086499,0.0004802171,0.00005001801,0.00125103,0.003539788,0.0002182725,0.002800891,0.00004308575],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929665,0.002245826,0.0004611792,0.0005405519,0.0001152144,0.001015113,0.001079253,0.00008402655,0.001492272],"genre_scores_gemma":[0.9913488,0.001316615,0.000984265,0.0008939981,0.0002457504,0.001307253,0.002253323,0.00003197743,0.00161806],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003146201,"threshold_uncertainty_score":0.01422727,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06797770056201222,"score_gpt":0.3335645383019249,"score_spread":0.2655868377399127,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}