{"id":"W3199414623","doi":"10.17863/cam.75702","title":"Association of germline genetic variants with breast cancer-specific survival in patient subgroups defined by clinic-pathological variables related to tumor biology and type of systemic treatment.","year":2021,"lang":"en","type":"article","venue":"Apollo (University of Cambridge)","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research and Materiel Command; Servicio Gallego de Salud; Universitätsklinikum Hamburg-Eppendorf; Instituto de Salud Carlos III; Cancer Council Tasmania; Cancer Council NSW; National Health and Medical Research Council; World Cancer Research Fund; Medical Research Council; Canadian Institutes of Health Research; Programme Grants for Applied Research; Manchester Biomedical Research Centre; University of California, San Francisco; Imperial Experimental Cancer Medicine Centre; National Institutes of Health; Hellenic Health Foundation; Freistaat Sachsen; Deutschen Konsortium für Translationale Krebsforschung; Xunta de Galicia; Mutuelle Générale de l'Education Nationale; Institut Gustave-Roussy; Norges Forskningsråd; Centers for Disease Control and Prevention; Institut National Du Cancer; Leids Universitair Medisch Centrum; Ministère de l'Économie, de la Science et de l'Innovation - Québec; Deutsche Krebshilfe; Institut National de la Santé et de la Recherche Médicale; University of Crete; Vetenskapsrådet; Stockholms Läns Landsting; Kuopion Yliopistollinen Sairaala; Harvard T.H. Chan School of Public Health; Karolinska Institutet; Government of Canada; Ministerio de Sanidad, Servicios Sociales e Igualdad; Bundesministerium für Bildung und Forschung; Ovarian Cancer Research Fund; Ministerio de Economía y Competitividad; Cancer Australia; Agence Nationale de la Recherche; Deutsche Gesetzliche Unfallversicherung; Gentofte Hospital; Deutsche Forschungsgemeinschaft; Robert Bosch Stiftung; Cancer Council South Australia; Fonds Wetenschappelijk Onderzoek; Cancerfonden; National Cancer Institute; Cancer Institute NSW; European Regional Development Fund; King's College London; National Institute for Health and Care Research; Stavros Niarchos Foundation; University of Southern California; Cancer Research UK; Eberhard Karls Universität Tübingen; Rheinische Friedrich-Wilhelms-Universität Bonn; Breast Cancer Research Trust; Fondation du cancer du sein du Québec; David F. and Margaret T. Grohne Family Foundation; U.S. Army; University of Westminster; Ligue Contre le Cancer; Deutsches Krebsforschungszentrum; Brigham and Women's Hospital; Associazione Italiana per la Ricerca sul Cancro; Genome Canada; Itä-Suomen Yliopisto; Fondation de France; Sundhed og Sygdom, Det Frie Forskningsråd; Cancer Council Victoria; California Department of Public Health; National Breast Cancer Foundation; Cancer Council Western Australia; European Commission; Breast Cancer Research Foundation","keywords":"Germline; Pathological; Breast cancer; Cancer; Oncology; Medicine; Biology; Internal medicine; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001179274,0.000347127,0.0004361026,0.0004966403,0.0003034458,0.0004453714,0.0003532641,0.000538082,0.001109467],"category_scores_gemma":[0.002747393,0.0001662051,0.0008949217,0.0005686089,0.0003706005,0.0002088148,0.0004011811,0.0005016376,0.00009421971],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001982352,"about_ca_system_score_gemma":0.0002167808,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001360281,"about_ca_topic_score_gemma":0.002387619,"domain_scores_codex":[0.9989126,0.0002860577,0.00009357907,0.0004077934,0.0001212191,0.0001788181],"domain_scores_gemma":[0.9975777,0.001057625,0.0008529836,0.0002818401,0.00006657846,0.0001632607],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007306268,0.0000210213,0.9925412,0.00001535366,0.0007018815,0.0001504815,0.00004465625,0.0002878895,0.002588512,0.00005252823,0.00007958735,0.002786242],"study_design_scores_gemma":[0.00005391,0.0001804527,0.995789,0.000004455217,0.000362846,0.000731014,0.0000558344,0.001599146,0.0006685365,0.0003091364,0.0002382285,0.000007401235],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988496,0.0003256371,0.0004109282,0.00003284195,0.00000491884,0.000004412315,0.000247873,0.000006198026,0.000117489],"genre_scores_gemma":[0.999662,0.000023119,0.00008708958,0.00001223963,0.000003925666,0.000003089414,0.0001752473,0.000001987081,0.00003132105],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001360281,"threshold_uncertainty_score":0.006236672,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009193373916155078,"score_gpt":0.2327947409624813,"score_spread":0.2236013670463262,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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