{"id":"W3199458823","doi":"10.3389/fncom.2021.653097","title":"A Neuron-Glial Model of Exosomal Release in the Onset and Progression of Alzheimer's Disease","year":2021,"lang":"en","type":"article","venue":"Frontiers in Computational Neuroscience","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Wilfrid Laurier University","funders":"Natural Sciences and Engineering Research Council of Canada; Agencia Estatal de Investigación; Basque Center for Applied Mathematics; Eusko Jaurlaritza; Ministerio de Ciencia, Innovación y Universidades","keywords":"Exosome; Microvesicles; Neuroscience; Neurotoxicity; Extracellular vesicles; Extracellular; Chemistry; Biology; Cell biology; Medicine; Biochemistry; Internal medicine; microRNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001399291,0.00007436919,0.00008894174,0.00005019478,0.00002852271,0.00001053895,0.0001873179,0.00002684086,5.30414e-7],"category_scores_gemma":[0.0002483966,0.00006665279,0.00003517354,0.0001914615,0.0003082684,0.000009260663,0.0001117822,0.00006653796,5.646141e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003299469,"about_ca_system_score_gemma":0.000239019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001155424,"about_ca_topic_score_gemma":0.000001226734,"domain_scores_codex":[0.9990129,0.0001356421,0.0002029942,0.0002895669,0.0002449236,0.000114007],"domain_scores_gemma":[0.999618,0.00002023776,0.00007975558,0.0001764412,0.00004826819,0.0000572967],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0004825167,0.0009646418,0.2665143,0.00008138174,0.000006192047,0.0001903588,0.0001797786,0.547855,0.1780325,0.0004615494,0.001098708,0.004133057],"study_design_scores_gemma":[0.0006444295,0.0001103594,0.2975744,0.00003538114,0.00001419458,0.00001532115,0.00006021183,0.6854238,0.01229579,0.003658809,0.00004112085,0.0001261873],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9832048,0.001278145,0.01492541,0.0002511705,0.0001277952,0.0001335352,0.00005715434,0.000001769377,0.00002024891],"genre_scores_gemma":[0.9910315,0.00003785348,0.008612434,0.0002613614,0.00001142287,0.000007132611,0.00002688978,0.00000560233,0.000005792102],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1657367,"threshold_uncertainty_score":0.2718022,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01663784360924117,"score_gpt":0.2738969429127723,"score_spread":0.2572590993035311,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}