{"id":"W3199491012","doi":"10.3390/vetsci8090200","title":"Mice Treated Subcutaneously with Mouse LPS-Converted PrPres or LPS Alone Showed Brain Gene Expression Profiles Characteristic of Prion Disease","year":2021,"lang":"en","type":"article","venue":"Veterinary Sciences","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Alberta Livestock and Meat Agency","keywords":"Lipopolysaccharide; Gene isoform; Escherichia coli; Recombinant DNA; Inflammation; Gene expression; Scrapie; Molecular biology; Gene; Neuroinflammation; Biology; Microbiology; Immunology; Medicine; Pathology; Prion protein; Disease; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001445505,0.0006247287,0.0005373719,0.0005452246,0.0001520856,0.0002096765,0.000165476,0.0004538201,0.002426631],"category_scores_gemma":[0.0001218506,0.0001841879,0.0003401544,0.0001798175,0.0004205971,0.0002402062,0.0001476984,0.001131717,0.0005632371],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000108341,"about_ca_system_score_gemma":0.0001292611,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002070811,"about_ca_topic_score_gemma":0.0003355246,"domain_scores_codex":[0.9997907,0.00002302197,0.00002211773,0.00007067839,0.00004608113,0.00004727412],"domain_scores_gemma":[0.999688,0.00004527362,0.00009495983,0.00003336988,0.00003243271,0.0001059039],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004721409,0.0001614207,0.0001824003,0.00002362866,0.000004914883,0.00005286321,0.00001554454,0.00001580439,0.9985336,0.0000157413,0.00001826512,0.000503756],"study_design_scores_gemma":[0.00009259338,0.008265861,0.01423523,0.00001597366,0.00004403123,0.0006808935,0.00008171493,0.0004451798,0.9747409,0.00006864485,0.001312191,0.00001686431],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960994,0.0004933808,0.001912012,0.00006789743,0.00004226857,0.00006823849,0.0005611691,0.00007008373,0.0006855658],"genre_scores_gemma":[0.9839352,0.000996344,0.004621014,0.0001602751,0.00004790746,0.0003297884,0.001993672,0.00004684506,0.007868879],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002426631,"threshold_uncertainty_score":0.008117855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02278116220202796,"score_gpt":0.267837898614262,"score_spread":0.245056736412234,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}