{"id":"W3199499776","doi":"10.1016/j.ocarto.2021.100213","title":"Safety and pharmacokinetics of EP-104IAR (sustained-release fluticasone propionate) in knee osteoarthritis: A randomized, double-blind, placebo-controlled phase 1 trial","year":2021,"lang":"en","type":"article","venue":"Osteoarthritis and Cartilage Open","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Fowler Kennedy Sport Medicine Clinic; Western University; Aurinia (Canada)","funders":"","keywords":"Medicine; Placebo; Osteoarthritis; Fluticasone propionate; Pharmacokinetics; Randomized controlled trial; Adverse effect; Internal medicine; Anesthesia; Clinical trial; Placebo-controlled study; Corticosteroid; Double blind","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001233612,0.0005535263,0.002735105,0.0002543478,0.0001956873,0.0002489261,0.0001621039,0.0002852944,0.0005574051],"category_scores_gemma":[0.0003096994,0.00050325,0.000342664,0.0004156638,0.0003383164,0.0003968189,0.0004006319,0.0003799257,0.00001207611],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006177289,"about_ca_system_score_gemma":0.0004364761,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004121208,"about_ca_topic_score_gemma":0.000394374,"domain_scores_codex":[0.9958721,0.0005252638,0.00149456,0.0008945084,0.000531029,0.0006824892],"domain_scores_gemma":[0.9979105,0.0003514175,0.0003465483,0.0005129175,0.0003580678,0.0005205462],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8395541,0.0009261611,0.00002672434,0.0001373522,0.00007517358,0.00208088,0.0004499096,0.000001301809,0.01825948,0.001758492,0.00002872734,0.1367016],"study_design_scores_gemma":[0.9526923,0.007867401,0.000001521026,0.0008720417,0.0008665795,0.0005892648,0.001213197,0.00006804636,0.03273721,0.0002387926,0.002409878,0.000443813],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9546509,0.02175026,0.00003224746,0.0007410463,0.0003564393,0.01463471,0.0001427193,0.00004613429,0.007645548],"genre_scores_gemma":[0.989246,0.00313699,0.0007952597,0.0002689735,0.0002007405,0.001776637,0.0002924455,0.00007993587,0.004203007],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1362578,"threshold_uncertainty_score":0.9997419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0176225876568166,"score_gpt":0.2985892307578249,"score_spread":0.2809666431010083,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}