{"id":"W3199502236","doi":"10.1182/blood.2021011121","title":"Clonal hematopoiesis in sickle cell disease","year":2021,"lang":"en","type":"letter","venue":"Blood","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine; Montreal Heart Institute","funders":"National Cancer Institute; Canadian Institutes of Health Research; Institut National de la Santé et de la Recherche Médicale; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Gilead Foundation; Gilead Sciences; Agence Nationale de la Recherche; Pfizer","keywords":"Disease; Immunology; Medicine; Haematopoiesis; Sickle cell anemia; Biology; Genetics; Internal medicine; Stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001561808,0.0005824416,0.0009418628,0.0008215812,0.004310196,0.002583462,0.0012821,0.05729657,0.005237719],"category_scores_gemma":[0.01113384,0.0006264593,0.0008588797,0.0005920282,0.002032743,0.001539233,0.001213193,0.02502364,0.00215921],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004434607,"about_ca_system_score_gemma":0.003440287,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008427645,"about_ca_topic_score_gemma":0.01850847,"domain_scores_codex":[0.9987444,0.0004543948,0.0001471834,0.0001259109,0.000244808,0.000283379],"domain_scores_gemma":[0.9963952,0.002334693,0.0002307038,0.00009084141,0.0003739727,0.0005746607],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000136646,0.00008653352,0.00335863,0.0001067291,0.00003059659,0.05534091,0.0004227757,0.0002200846,0.0005164017,0.01231081,0.9148545,0.01261534],"study_design_scores_gemma":[0.0003464139,0.0002130481,0.008199554,0.001209583,0.0001560695,0.05343836,0.001148777,0.00267888,0.0006381554,0.03385388,0.898015,0.0001022871],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.003059211,0.003560797,0.0001775793,0.9512804,0.01803787,0.00003220483,0.00005174171,0.00002369744,0.02377652],"genre_scores_gemma":[0.0363756,0.003341163,0.0004174074,0.8355382,0.09845027,0.00007125203,0.00005209034,0.00003536376,0.02571866],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.05729657,"threshold_uncertainty_score":0.03217542,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008298040455545483,"score_gpt":0.2128795344753746,"score_spread":0.2045814940198291,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}