{"id":"W3199502236","doi":"10.1182/blood.2021011121","title":"Clonal hematopoiesis in sickle cell disease","year":2021,"lang":"en","type":"letter","venue":"Blood","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine; Montreal Heart Institute","funders":"National Cancer Institute; Canadian Institutes of Health Research; Institut National de la Santé et de la Recherche Médicale; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Gilead Foundation; Gilead Sciences; Agence Nationale de la Recherche; Pfizer","keywords":"Disease; Immunology; Medicine; Haematopoiesis; Sickle cell anemia; Biology; Genetics; Internal medicine; Stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00006121872,0.0002809057,0.0005143766,0.0001518463,0.00003645869,0.00002170354,0.0001078886,0.0007210747,0.0008290572],"category_scores_gemma":[0.00005639225,0.0002460032,0.0002703277,0.0002403603,0.0000591882,0.00002253366,0.00006756321,0.001638155,0.0001774055],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003358545,"about_ca_system_score_gemma":0.0004292025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003941531,"about_ca_topic_score_gemma":0.000003722649,"domain_scores_codex":[0.9983917,0.0000547025,0.0003177231,0.000436914,0.0003795327,0.0004193806],"domain_scores_gemma":[0.9992005,0.00005397028,0.00007459809,0.0004620313,0.00005028658,0.0001586615],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002485798,0.0009008755,0.004132854,0.001709367,0.0001156201,0.02939417,0.0000971254,0.000001405713,0.0001176018,0.000006782931,0.9634133,0.00008606],"study_design_scores_gemma":[0.004782348,0.00007285934,0.001473762,0.001027468,0.001097109,0.0001761634,0.0001226969,0.000009727114,0.0006655477,0.0001122295,0.9899902,0.0004699396],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.09659751,0.02043523,0.000003778983,0.8542207,0.0005154802,0.0006249035,0.0001044367,0.0001191354,0.02737887],"genre_scores_gemma":[0.02188901,0.001444145,0.0003132621,0.941741,0.002765631,0.00008365688,0.002014935,0.0001727891,0.0295756],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.08752031,"threshold_uncertainty_score":0.9999992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008298040455545483,"score_gpt":0.2128795344753746,"score_spread":0.2045814940198291,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}