{"id":"W3199505500","doi":"10.7554/elife.67075.sa2","title":"Author response: Precise optical control of gene expression in C elegans using improved genetic code expansion and Cre recombinase","year":2021,"lang":"en","type":"peer-review","venue":"","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"","keywords":"Recombinase; Biology; Genetics; Caenorhabditis elegans; Cre recombinase; Gene expression; Gene; Computational biology; Recombination; Transgene; Genetically modified mouse","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001256108,0.0008059189,0.0004716581,0.0005884593,0.0007860662,0.001099949,0.0007794552,0.003682459,0.06219045],"category_scores_gemma":[0.002681117,0.0003719823,0.0006072223,0.0002752106,0.0006014173,0.0006724038,0.0009684648,0.003157633,0.02156425],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008520388,"about_ca_system_score_gemma":0.0007398929,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001469409,"about_ca_topic_score_gemma":0.003249299,"domain_scores_codex":[0.9989917,0.00008802232,0.00006188816,0.0001990462,0.0005240659,0.0001352014],"domain_scores_gemma":[0.9982065,0.0003747989,0.0001300025,0.00008966588,0.0009014758,0.000297566],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001457991,0.0001937812,0.001133947,0.0009945767,0.00008641357,0.0008195115,0.0002542264,0.0007416994,0.1469897,0.003034892,0.7679014,0.07639185],"study_design_scores_gemma":[0.0001936307,0.0003578234,0.004130736,0.0002329208,0.00005537447,0.0004146267,0.0004238915,0.0008644356,0.05451705,0.0007907266,0.9379349,0.00008380375],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.06423964,0.01701734,0.02083297,0.339108,0.3078459,0.00162983,0.004202098,0.007493712,0.2376307],"genre_scores_gemma":[0.09882843,0.007200224,0.01398819,0.104003,0.01222827,0.0006918421,0.002570892,0.001092108,0.759397],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.06219045,"threshold_uncertainty_score":0.2080477,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02443770254534734,"score_gpt":0.3017216983560452,"score_spread":0.2772839958106979,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}