{"id":"W3199521922","doi":"10.1016/j.celrep.2021.109705","title":"TCF/LEF regulation of the topologically associated domain ADI promotes mESCs to exit the pluripotent ground state","year":2021,"lang":"en","type":"article","venue":"Cell Reports","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; McMaster University Medical Centre; McMaster University","funders":"Canadian Institutes of Health Research; National Science Foundation; Vetenskapsrådet; Knut och Alice Wallenbergs Stiftelse; Cancerfonden; Functional Genomics Center Zurich; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Cell biology; Domain (mathematical analysis); Induced pluripotent stem cell; Biology; Physics; Mathematics; Embryonic stem cell; Genetics; Gene; Mathematical analysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007728425,0.0002347076,0.0001102592,0.0001815714,0.0001138941,0.0002611268,0.0001283737,0.0001127347,0.0009328155],"category_scores_gemma":[0.00007424279,0.00009158819,0.000127071,0.00006777271,0.0002082183,0.0001277898,0.000221705,0.0003159052,0.000304894],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002878958,"about_ca_system_score_gemma":0.0001558197,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004793276,"about_ca_topic_score_gemma":0.001465603,"domain_scores_codex":[0.9999176,0.00001250708,0.000009211596,0.00001794162,0.00002450473,0.000018225],"domain_scores_gemma":[0.9999217,0.00001288235,0.00002367019,0.000009264864,0.00000819045,0.00002419215],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002151239,0.000003555991,0.0001707487,0.000006806772,9.385568e-7,0.00002042424,0.000004112597,0.0000264848,0.9993604,0.00007001179,0.000008595543,0.000306388],"study_design_scores_gemma":[0.000003758245,0.00002655429,0.002442373,0.000001322881,0.000002421777,0.00006581947,0.00001287532,0.0003468122,0.9962464,0.00001478854,0.0008357014,0.000001273963],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949617,0.0003967326,0.003079246,0.00003634303,0.0000113525,0.00001182212,0.0002362818,0.00007393137,0.001192647],"genre_scores_gemma":[0.9966343,0.0001187922,0.001101855,0.00001595151,0.00000220377,0.00001323781,0.0003219691,0.00001707787,0.001774603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009328155,"threshold_uncertainty_score":0.003120542,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01226201439411911,"score_gpt":0.2444282596648374,"score_spread":0.2321662452707183,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}