{"id":"W3199551270","doi":"10.3390/pharmaceutics13091509","title":"Inhibition of Scavenger Receptor Class B Type 1 (SR-B1) Expression and Activity as a Potential Novel Target to Disrupt Cholesterol Availability in Castration-Resistant Prostate Cancer","year":2021,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; University of British Columbia","funders":"","keywords":"Prostate cancer; Androgen receptor; Androgen deprivation therapy; Scavenger receptor; Cancer research; Cholesterol; Cancer; Prostate; Androgen; Internal medicine; Testosterone (patch); Cancer cell; Endocrinology; Medicine; Biology; Chemistry; Hormone; Lipoprotein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001585135,0.0001306772,0.0001645504,0.00003302418,0.00004228513,0.00002001753,0.000044524,0.00009325428,0.00006042848],"category_scores_gemma":[0.00006288868,0.0001343541,0.0000395677,0.0001259639,0.00005639676,0.00001387414,0.0000968292,0.0001199609,0.000002122611],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003631106,"about_ca_system_score_gemma":0.0002176549,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007992547,"about_ca_topic_score_gemma":0.0002463912,"domain_scores_codex":[0.9990469,0.00007275685,0.0002067831,0.0003444526,0.00014224,0.0001868824],"domain_scores_gemma":[0.9994388,0.000007250737,0.0000835815,0.0001810206,0.0001778712,0.0001114786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000744062,0.0001927173,0.001762795,0.00008913085,0.0000162613,3.295065e-7,0.0002787886,0.0002744157,0.993153,0.000002876983,0.0007890308,0.002696623],"study_design_scores_gemma":[0.001141775,0.00006520329,0.006823056,0.00004321782,0.00002236936,0.000003528884,0.00007888279,0.0001000077,0.9032723,0.000008004889,0.08830418,0.0001374398],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960583,0.001306609,0.0001678805,0.0003322847,0.001542537,0.0002929626,0.00023773,0.000005474614,0.00005616578],"genre_scores_gemma":[0.996718,0.001184272,0.0005118922,0.0002436388,0.0009349847,0.00003696914,0.0000798686,0.00001614572,0.0002741615],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08988065,"threshold_uncertainty_score":0.5478802,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02355258767262556,"score_gpt":0.3248339177528285,"score_spread":0.3012813300802029,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}