{"id":"W3199562573","doi":"10.1038/s41531-021-00231-5","title":"Fine mapping of the HLA locus in Parkinson’s disease in Europeans","year":2021,"lang":"en","type":"article","venue":"npj Parkinson s Disease","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill Genome Centre; Montreal Neurological Institute and Hospital","funders":"Fonds de Recherche du Québec - Santé; Avid Radiopharmaceuticals; Sanofi Genzyme; Genentech; H. Lundbeck A/S; Servier; Allergan; National Institutes of Health; Bristol-Myers Squibb; Consortium canadien en neurodégénérescence associée au vieillissement; Canada First Research Excellence Fund; Parkinson Canada; Voyager Therapeutics; Denali Therapeutics; Neurocrine Biosciences; McGill University; Pfizer; Biogen; Celgene; Verily Life Sciences; Teva Pharmaceutical Industries; Sanofi; GlaxoSmithKline; Eli Lilly and Company; Michael J. Fox Foundation for Parkinson's Research","keywords":"Human leukocyte antigen; Locus (genetics); Parkinson's disease; Disease; Haplotype; Genetics; Genetic association; Allele; Biology; Immunology; Medicine; Antigen; Internal medicine; Single-nucleotide polymorphism; Genotype; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002567466,0.0002891551,0.0004222875,0.0001902503,0.0001119352,0.00001625371,0.0005063959,0.0001547326,0.0008983797],"category_scores_gemma":[0.0003310153,0.0002371176,0.000231966,0.0006393432,0.0003537902,0.00008534413,0.0003668955,0.0005098426,0.0003043649],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007957278,"about_ca_system_score_gemma":0.0003780996,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001928373,"about_ca_topic_score_gemma":0.0005039291,"domain_scores_codex":[0.9972376,0.0008842426,0.0006063685,0.0006036525,0.00008162078,0.0005865671],"domain_scores_gemma":[0.9986508,0.00014741,0.0001822448,0.0008510147,0.00007339385,0.00009508077],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006285592,0.001121884,0.6161268,0.0001030495,0.00006412832,0.0005723404,0.000398393,0.0001244634,0.3754138,0.0003749681,0.001671801,0.003399724],"study_design_scores_gemma":[0.002194141,0.00002157912,0.5918022,0.0001819742,0.00004629505,0.000008256903,0.0001361592,0.00002018656,0.01794159,0.0002505532,0.3871457,0.0002512964],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.976479,0.0195459,0.000014312,0.001319374,0.0007881727,0.0002973634,0.0001395898,0.00004188676,0.001374397],"genre_scores_gemma":[0.9949988,0.0004085226,0.00001453199,0.0003974091,0.00003570721,0.00004554362,0.0001116201,0.00003247501,0.003955432],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3854739,"threshold_uncertainty_score":0.9836628,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01446825782639908,"score_gpt":0.2184390479776928,"score_spread":0.2039707901512938,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}