{"id":"W3199562573","doi":"10.1038/s41531-021-00231-5","title":"Fine mapping of the HLA locus in Parkinson’s disease in Europeans","year":2021,"lang":"en","type":"article","venue":"npj Parkinson s Disease","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill Genome Centre; Montreal Neurological Institute and Hospital","funders":"Fonds de Recherche du Québec - Santé; Avid Radiopharmaceuticals; Sanofi Genzyme; Genentech; H. Lundbeck A/S; Servier; Allergan; National Institutes of Health; Bristol-Myers Squibb; Consortium canadien en neurodégénérescence associée au vieillissement; Canada First Research Excellence Fund; Parkinson Canada; Voyager Therapeutics; Denali Therapeutics; Neurocrine Biosciences; McGill University; Pfizer; Biogen; Celgene; Verily Life Sciences; Teva Pharmaceutical Industries; Sanofi; GlaxoSmithKline; Eli Lilly and Company; Michael J. Fox Foundation for Parkinson's Research","keywords":"Human leukocyte antigen; Locus (genetics); Parkinson's disease; Disease; Haplotype; Genetics; Genetic association; Allele; Biology; Immunology; Medicine; Antigen; Internal medicine; Single-nucleotide polymorphism; Genotype; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000824166,0.0001828613,0.000242939,0.0008555904,0.0003970779,0.0003741282,0.0001648422,0.0003521545,0.002118079],"category_scores_gemma":[0.001934285,0.0001409909,0.0002401718,0.0008202169,0.0003397362,0.0001626599,0.0003690749,0.0002657651,0.0002184357],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001379871,"about_ca_system_score_gemma":0.00009292786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002129875,"about_ca_topic_score_gemma":0.001435365,"domain_scores_codex":[0.9994777,0.0002228204,0.00004990498,0.0001473619,0.00005161756,0.00005059476],"domain_scores_gemma":[0.9990661,0.0003335416,0.0002838587,0.00009288671,0.00009758034,0.0001262178],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007434897,0.00004877145,0.9721088,0.00002206868,0.0001673954,0.0006577701,0.0004088045,0.0001631295,0.01666254,0.0002313012,0.0001185341,0.008667314],"study_design_scores_gemma":[0.0000284584,0.0001505007,0.9965943,0.00001429126,0.00004876895,0.001297178,0.0001755111,0.0002210739,0.0007750214,0.0001676627,0.0005224148,0.000004867953],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991146,0.0001865805,0.0002856595,0.00002506625,0.000003564135,0.00000274056,0.00005838736,0.000001964949,0.0003212935],"genre_scores_gemma":[0.9997056,0.00004277275,0.0001025415,0.00001227914,0.00000336223,0.000001733083,0.00005375563,0.000001144747,0.00007671332],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002129875,"threshold_uncertainty_score":0.007085681,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01446825782639908,"score_gpt":0.2184390479776928,"score_spread":0.2039707901512938,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}