{"id":"W3199606554","doi":"10.1038/s41467-021-25670-9","title":"Genetic variations of DNA bindings of FOXA1 and co-factors in breast cancer susceptibility","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"FOXO transcription factor regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital","funders":"National Cancer Institute; National Institutes of Health; Vanderbilt University","keywords":"FOXA1; Breast cancer; Genome-wide association study; Transcription factor; Biology; Genetics; Computational biology; Chromatin; Gene; Enhancer; Transcriptome; Genetic predisposition; Cancer; Single-nucleotide polymorphism; Genotype; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008596223,0.00007133278,0.0001137904,0.00005722208,0.00004424275,0.000005474445,0.0002025025,0.0002022699,0.00002808497],"category_scores_gemma":[0.00006190346,0.00007515417,0.0000454054,0.0002077713,0.000143027,0.000005869393,0.00007580022,0.000159353,1.981065e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001948514,"about_ca_system_score_gemma":0.0001024905,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001054437,"about_ca_topic_score_gemma":0.002624433,"domain_scores_codex":[0.9993716,0.0001030382,0.0002236337,0.0001489939,0.00008003139,0.00007262745],"domain_scores_gemma":[0.9988857,0.00003659882,0.00009914269,0.000733561,0.0002168367,0.00002818273],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000006122457,0.00007407669,0.418431,0.00001310136,0.00001718325,3.424943e-8,0.0001048461,0.00001481454,0.5806255,0.0005225399,0.0000698257,0.0001209534],"study_design_scores_gemma":[0.0002017196,0.00001231301,0.8877533,0.00001574313,0.00001743027,0.000003430155,0.00008613143,0.00005815456,0.1106065,0.00006265633,0.001120691,0.00006191728],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962593,0.002379464,0.00006766101,0.0006870351,0.00004906307,0.0001027227,0.0003085362,0.000004120727,0.0001420871],"genre_scores_gemma":[0.9971815,0.0009755209,0.001444845,0.00002966839,0.000009249062,0.000008944889,0.0003155717,0.000007679156,0.00002705005],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.470019,"threshold_uncertainty_score":0.3064698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01407353283702945,"score_gpt":0.29440797058835,"score_spread":0.2803344377513206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}