{"id":"W3199609442","doi":"10.1158/1541-7786.mcr-21-0471","title":"Mutations in Noncoding <i>Cis</i> -Regulatory Elements Reveal Cancer Driver Cistromes in Luminal Breast Cancer","year":2021,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Vector Institute; Amgen (Canada); Ontario Institute for Cancer Research; University Health Network; University of Toronto; Princess Margaret Cancer Centre","funders":"Canadian Institutes of Health Research","keywords":"Breast cancer; Transcription factor; FOXA1; Chromatin; Estrogen receptor; Cancer; Gene; Transcription (linguistics)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001582479,0.000189733,0.0002580227,0.0005270899,0.0001674794,0.000371938,0.000148414,0.0002443996,0.001547314],"category_scores_gemma":[0.0002713387,0.0001556432,0.0002219099,0.0004136603,0.000193382,0.0001288335,0.0002882509,0.0003285771,0.0005080538],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001866035,"about_ca_system_score_gemma":0.0001638673,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008358959,"about_ca_topic_score_gemma":0.002768001,"domain_scores_codex":[0.9998677,0.000009957219,0.000008596209,0.00005522151,0.00003781954,0.00002075108],"domain_scores_gemma":[0.9997839,0.00005435155,0.00007761709,0.0000301725,0.00002107447,0.00003283138],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000155995,0.0000163401,0.02882517,0.00008814887,0.00004754155,0.0001855186,0.0000621316,0.0005325693,0.9623811,0.0004579073,0.000209419,0.007038167],"study_design_scores_gemma":[0.00002196614,0.0002000272,0.5137227,0.00005911287,0.0001978366,0.002926143,0.0002680366,0.009052337,0.4616044,0.002235724,0.009669813,0.00004182442],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871334,0.0008386784,0.007162871,0.00007415034,0.0000150216,0.00001930678,0.002918637,0.0002416195,0.001596228],"genre_scores_gemma":[0.9939469,0.0002412746,0.003079917,0.00009183181,0.000006893379,0.00001060386,0.001987617,0.000045154,0.0005898492],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001547314,"threshold_uncertainty_score":0.005176246,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01850999249806132,"score_gpt":0.3428045346789499,"score_spread":0.3242945421808886,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}