{"id":"W3199609442","doi":"10.1158/1541-7786.mcr-21-0471","title":"Mutations in Noncoding <i>Cis</i> -Regulatory Elements Reveal Cancer Driver Cistromes in Luminal Breast Cancer","year":2021,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Vector Institute; Amgen (Canada); Ontario Institute for Cancer Research; University Health Network; University of Toronto; Princess Margaret Cancer Centre","funders":"Canadian Institutes of Health Research","keywords":"Breast cancer; Transcription factor; FOXA1; Chromatin; Estrogen receptor; Cancer; Gene; Transcription (linguistics)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000456464,0.0001949443,0.000227303,0.0001815025,0.0001126594,0.00006396703,0.0003210091,0.000163812,0.00020377],"category_scores_gemma":[0.00003136481,0.0002253673,0.00009233138,0.0005860127,0.0001475818,0.000009387953,0.0003273202,0.0003806564,0.000005074765],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005073911,"about_ca_system_score_gemma":0.001205374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002558099,"about_ca_topic_score_gemma":0.01307274,"domain_scores_codex":[0.9975643,0.0002233582,0.0003716013,0.0006480042,0.000495061,0.000697671],"domain_scores_gemma":[0.9990347,0.00001394406,0.0000704764,0.0004259415,0.0003241477,0.000130805],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000063669,0.0001096495,0.1109644,0.00007234266,0.00006577922,0.0001906254,0.0001423905,0.003065332,0.8800711,0.00006274084,0.0007996797,0.004392258],"study_design_scores_gemma":[0.004109148,0.0001360843,0.4436494,0.000598198,0.00004752585,0.0000688649,0.0009207077,0.002276701,0.5383884,0.0004588729,0.008347415,0.0009987307],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934472,0.004273874,0.0000724215,0.001050113,0.0001846082,0.0002713036,0.0002826424,0.000005432183,0.0004123944],"genre_scores_gemma":[0.9958439,0.001766911,0.0003084405,0.0002409748,0.0001969426,0.000485716,0.0001557889,0.0000492818,0.0009520118],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3416827,"threshold_uncertainty_score":0.9190213,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01850999249806132,"score_gpt":0.3428045346789499,"score_spread":0.3242945421808886,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}