{"id":"W3199656628","doi":"10.4049/jimmunol.2100108","title":"Selective Induction of Cell Death in Human M1 Macrophages by Smac Mimetics Is Mediated by cIAP-2 and RIPK-1/3 through the Activation of mTORC","year":2021,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University; Ottawa Hospital; Children's Hospital of Eastern Ontario; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Programmed cell death; Cell biology; Macrophage; Kinase; Caspase; Proinflammatory cytokine; Cancer research; Biology; Apoptosis; Inflammation; Immunology; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002355682,0.0003148922,0.0002101875,0.0002301674,0.0001706928,0.00017061,0.00009728827,0.0001785644,0.0009382032],"category_scores_gemma":[0.00007940247,0.0001018945,0.0002316367,0.0001396755,0.0001315345,0.00009564129,0.0001442083,0.0003132913,0.0003419782],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001542596,"about_ca_system_score_gemma":0.0001736711,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002032141,"about_ca_topic_score_gemma":0.0003080275,"domain_scores_codex":[0.9998665,0.00003477064,0.00001542223,0.00001968842,0.00002404666,0.00003957409],"domain_scores_gemma":[0.9999249,0.00001261518,0.00002409919,0.000008299598,0.00001336318,0.00001680846],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000402308,0.00003166314,0.0003299854,0.0000569592,0.00000503095,0.00006978914,0.00002125219,0.00003483238,0.9976758,0.00009216508,0.00005785122,0.001222298],"study_design_scores_gemma":[0.00002155779,0.0004487153,0.003084453,0.00000579257,0.00001017929,0.0003067537,0.00001765879,0.0002457421,0.9941074,0.00002624383,0.001723372,0.000002132706],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913633,0.003440423,0.0027568,0.00008232644,0.00002521639,0.0000562098,0.0004296173,0.00005095081,0.001795248],"genre_scores_gemma":[0.9938053,0.001740789,0.002205875,0.0000674397,0.00001438219,0.0000968204,0.0005835488,0.00001074882,0.001475184],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009382032,"threshold_uncertainty_score":0.003138602,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01141341955844625,"score_gpt":0.2495302114532386,"score_spread":0.2381167918947924,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}