{"id":"W3199660841","doi":"10.1261/rna.078953.121","title":"Dyskerin: an essential pseudouridine synthase with multifaceted roles in ribosome biogenesis, splicing, and telomere maintenance","year":2021,"lang":"en","type":"review","venue":"RNA","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research; McGill University","keywords":"Biology; Pseudouridine; Ribosome biogenesis; RNA splicing; Telomere; Biogenesis; Genetics; Ribosome; RNA; Computational biology; Cell biology; Transfer RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001606538,0.000656102,0.0007090924,0.001161969,0.0002146864,0.0008299075,0.0003913383,0.0005730718,0.001475232],"category_scores_gemma":[0.0001958214,0.000171025,0.00023055,0.001319697,0.0002461575,0.0009219259,0.0004081659,0.0007362514,0.001145756],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005823611,"about_ca_system_score_gemma":0.0005320107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004228433,"about_ca_topic_score_gemma":0.0005100947,"domain_scores_codex":[0.9998918,0.000008469052,0.00001771514,0.00002869714,0.00003894939,0.00001428917],"domain_scores_gemma":[0.9999213,0.00001854805,0.00002432897,0.000001925688,0.00001706855,0.00001686386],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002294377,0.0000612425,0.001110157,0.009834004,0.00012127,0.001239947,0.0001453471,0.0006671306,0.07254229,0.004841059,0.01985488,0.8893532],"study_design_scores_gemma":[0.0000117882,0.0001230845,0.003226539,0.0006997347,0.0001222887,0.005375957,0.00007075546,0.0002150265,0.01307273,0.001842493,0.9752103,0.00002926013],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002453668,0.9931511,0.0008726518,0.0002850831,0.0003346209,0.000009631802,0.00009041465,0.00005401151,0.002748846],"genre_scores_gemma":[0.009680309,0.984351,0.00104033,0.0003196846,0.0004499663,0.00001390608,0.0004534122,0.00001080689,0.003680581],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001475232,"threshold_uncertainty_score":0.004935205,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01747013567135849,"score_gpt":0.3022677667635519,"score_spread":0.2847976310921934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}