{"id":"W3199660841","doi":"10.1261/rna.078953.121","title":"Dyskerin: an essential pseudouridine synthase with multifaceted roles in ribosome biogenesis, splicing, and telomere maintenance","year":2021,"lang":"en","type":"review","venue":"RNA","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research; McGill University","keywords":"Biology; Pseudouridine; Ribosome biogenesis; RNA splicing; Telomere; Biogenesis; Genetics; Ribosome; RNA; Computational biology; Cell biology; Transfer RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001086439,0.0003391106,0.0006770747,0.00009040747,0.0000611337,0.00005208469,0.0001990829,0.0002663784,0.00002441808],"category_scores_gemma":[0.00002110305,0.0002663786,0.0001135032,0.0002108877,0.00008866504,0.000005623266,0.0000904453,0.0001418152,0.00000399121],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003075063,"about_ca_system_score_gemma":0.0002317197,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007480985,"about_ca_topic_score_gemma":0.0002462635,"domain_scores_codex":[0.9985366,0.00009536388,0.0003128737,0.0006782078,0.0001034222,0.0002735035],"domain_scores_gemma":[0.9990404,0.000007010103,0.0001817057,0.0005919331,0.00006878789,0.0001101654],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004488404,0.0002093664,0.00009866761,0.002456367,0.0002472578,0.00008599453,0.00002924354,0.00002100892,0.02295104,0.0000980348,0.0003641169,0.973394],"study_design_scores_gemma":[0.0005120773,0.0001581916,0.00008660017,0.00405761,0.0002587306,0.000181681,0.00007923565,0.00003049678,0.006202582,0.000001963945,0.9877566,0.0006742914],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.04067944,0.9585471,0.0001286,0.00003312133,0.00005633228,0.0003332316,0.0001491319,0.00001049077,0.00006256765],"genre_scores_gemma":[0.01070736,0.9873662,0.00043874,0.00002420411,0.0002094184,0.0001418241,0.0006650119,0.00006017235,0.0003870819],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9873924,"threshold_uncertainty_score":0.9999788,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01747013567135849,"score_gpt":0.3022677667635519,"score_spread":0.2847976310921934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}