{"id":"W3199662256","doi":"10.1016/j.fertnstert.2021.07.907","title":"A DNA METHYLATION SIGNATURE TO PATERNAL GERMLINE AGE AND ASSOCIATION WITH INFERTILITY","year":2021,"lang":"en","type":"article","venue":"Fertility and Sterility","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Decipher Biosciences (Canada)","funders":"","keywords":"Sperm; Infertility; DNA methylation; Male infertility; Epigenetics; Fertility; Sperm motility; Andrology; Biology; Semen analysis; Semen; Methylation; Physiology; Medicine; Genetics; Population; Pregnancy; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003269752,0.0002103699,0.0001978117,0.0008035888,0.0002385679,0.0003255975,0.0002501114,0.0003548796,0.003312385],"category_scores_gemma":[0.001370178,0.0001503329,0.0002962931,0.0005924654,0.0002215015,0.0001677028,0.000263161,0.0003167952,0.0002555516],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001209117,"about_ca_system_score_gemma":0.0001489782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001129617,"about_ca_topic_score_gemma":0.001281561,"domain_scores_codex":[0.9998181,0.00004555507,0.00001858973,0.00005165829,0.00003234093,0.0000337741],"domain_scores_gemma":[0.9990503,0.0003019743,0.0003526821,0.00006013513,0.00008822726,0.0001466914],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006425692,0.00003984625,0.9608074,0.00002662296,0.0001305673,0.0005896926,0.0001623212,0.0001181975,0.03119831,0.0001748123,0.0001115066,0.005998082],"study_design_scores_gemma":[0.000006858701,0.00009396551,0.9950982,0.000005137533,0.00004821879,0.001885989,0.00008306572,0.0002513418,0.002032867,0.0001444072,0.0003447642,0.000005245966],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980311,0.0004722223,0.0004658285,0.00006514757,0.00001226138,0.00000242514,0.0002251166,0.000009475386,0.0007163431],"genre_scores_gemma":[0.9991083,0.0001016772,0.0001603144,0.00001673599,0.00001105099,0.000001380985,0.00007543893,0.000003207122,0.0005218592],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003312385,"threshold_uncertainty_score":0.01108104,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01077736285613512,"score_gpt":0.248315461259683,"score_spread":0.2375380984035479,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}