{"id":"W3199689348","doi":"10.1152/ajplung.00574.2020","title":"A cGAS-dependent response links DNA damage and senescence in alveolar epithelial cells: a potential drug target in IPF","year":2021,"lang":"en","type":"article","venue":"American Journal of Physiology-Lung Cellular and Molecular Physiology","topic":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Providence Health Care Research Institute","funders":"National Health and Medical Research Council; Department of Health and Aged Care, Australian Government; Rijksuniversiteit Groningen; European Commission","keywords":"Senescence; DNA damage; Biology; Cancer research; Telomere; Idiopathic pulmonary fibrosis; Cell biology; Gene knockdown; Cell culture; Medicine; DNA; Biochemistry; Lung; Genetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001571649,0.0002831976,0.0004201901,0.0003247756,0.0001408103,0.0002651183,0.0002188649,0.0003546462,0.0008516756],"category_scores_gemma":[0.0001036128,0.0001085506,0.0002671202,0.0001943243,0.0001320878,0.0001807306,0.0001443073,0.0006675256,0.0002517385],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000197767,"about_ca_system_score_gemma":0.0001434664,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001478187,"about_ca_topic_score_gemma":0.0004661873,"domain_scores_codex":[0.9999355,0.00001316469,0.000006999055,0.00001539765,0.00001285185,0.00001596164],"domain_scores_gemma":[0.9999468,0.000008333409,0.00001599739,0.000007152682,0.00001031463,0.00001137162],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003899397,0.0002060784,0.000308156,0.0002489531,0.00001908115,0.0001164242,0.00002416463,0.0001363552,0.9823884,0.0002031516,0.0002223015,0.01573691],"study_design_scores_gemma":[0.0002613097,0.004431248,0.00982136,0.00006365516,0.00007619165,0.001099393,0.0000566628,0.001228096,0.9652273,0.0002304117,0.01748767,0.00001668258],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9344236,0.05476515,0.005637426,0.0007365643,0.0001854382,0.0002487728,0.0007751883,0.0003801155,0.002847612],"genre_scores_gemma":[0.9857978,0.01001055,0.001841078,0.000154738,0.00003340575,0.0001119862,0.0006003139,0.00001055632,0.001439602],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008516756,"threshold_uncertainty_score":0.002849102,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0026065559473821,"score_gpt":0.2198865719966688,"score_spread":0.2172800160492867,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}