{"id":"W3199710820","doi":"10.3390/ph14090914","title":"In Silico-Based Design and In Vivo Evaluation of an Anthranilic Acid Derivative as a Multitarget Drug in a Diet-Induced Metabolic Syndrome Model","year":2021,"lang":"en","type":"article","venue":"Pharmaceuticals","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; University of Toronto","funders":"Consejo Nacional de Ciencia y Tecnología","keywords":"Metabolic syndrome; Pharmacology; Medicine; In silico; Polypharmacy; Drug; Context (archaeology); Diabetes mellitus; In vivo; Population; Internal medicine; Endocrinology; Chemistry; Biology; Biochemistry; Biotechnology; Environmental health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001209812,0.0002055762,0.0003584326,0.0001834058,0.00002231376,0.00001334624,0.0001220784,0.0001630837,0.00007803035],"category_scores_gemma":[0.0004964778,0.0002156561,0.00004138013,0.0004107263,0.00007505522,0.00003045382,0.00006835316,0.0002105411,0.000001576755],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000573187,"about_ca_system_score_gemma":0.0004459054,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003469332,"about_ca_topic_score_gemma":0.00007829337,"domain_scores_codex":[0.9975463,0.0009643561,0.0003869523,0.0005060252,0.0002812263,0.0003152049],"domain_scores_gemma":[0.9993715,0.00005413967,0.00007294527,0.0002221527,0.0001534432,0.0001258405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005000415,0.0005122288,0.00192644,0.00002862324,0.0000320192,0.00001910845,0.0003190002,0.01281352,0.9833371,0.000007446231,0.000004085455,0.0005003772],"study_design_scores_gemma":[0.002772405,0.00007990848,0.0007243744,0.00002679907,0.00002520652,0.000007409803,0.00009668965,0.238407,0.7575207,0.0001539876,0.00001900108,0.0001664954],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996725,0.002012366,0.0003423741,0.0001862886,0.00003855691,0.0006455224,0.00001722096,0.000006746825,0.00002598025],"genre_scores_gemma":[0.9969796,0.0002059136,0.002188298,0.0003619014,0.00001242756,0.0001969853,0.00002429558,0.00002587011,0.00000469689],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2258164,"threshold_uncertainty_score":0.87942,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05876240138419424,"score_gpt":0.377603401964916,"score_spread":0.3188410005807218,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}