{"id":"W3199782511","doi":"10.1101/2021.09.23.461493","title":"Computationally designed GPCR quaternary structures bias signaling pathway activation","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Canadian Institutes of Health Research; Université de Montréal; Fondation pour la Recherche Médicale; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Fonds National de la Recherche Luxembourg; École Polytechnique Fédérale de Lausanne; Fonds Wetenschappelijk Onderzoek; Ludwig Institute for Cancer Research; National Science Foundation","keywords":"Protein quaternary structure; G protein-coupled receptor; Receptor; Signal transduction; Cell biology; Chemokine receptor; Biology; Chemistry; Biophysics; Chemokine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000282809,0.000494686,0.0005466366,0.0002932568,0.0003418185,0.000508281,0.0004143929,0.00057363,0.001931441],"category_scores_gemma":[0.0004619488,0.000267507,0.0003428295,0.0002070404,0.0002988708,0.0003029191,0.0002526281,0.0004543417,0.0002303433],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007556101,"about_ca_system_score_gemma":0.0009335451,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002056669,"about_ca_topic_score_gemma":0.003326104,"domain_scores_codex":[0.9999214,0.00002087258,0.000003234262,0.00001685926,0.00001609116,0.00002151895],"domain_scores_gemma":[0.9998652,0.00006411187,0.00001715033,0.00001044933,0.00002739899,0.00001569699],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000186525,0.0001159221,0.001602592,0.00008465155,0.00002637426,0.0001649435,0.00002708683,0.9722117,0.01576458,0.004548746,0.0004895867,0.004777306],"study_design_scores_gemma":[0.00002797528,0.00006368518,0.0001824997,0.000004003073,0.00001170188,0.00001298117,0.0000173117,0.9947929,0.003857824,0.0007079953,0.000316588,0.000004581972],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.95425,0.0002113332,0.03713991,0.0001981004,0.00003270738,0.00005357443,0.0003923841,0.0004538937,0.007268064],"genre_scores_gemma":[0.9810678,0.0001203511,0.01733779,0.00005984108,0.000006286306,0.00007061272,0.0004149791,0.00006151255,0.000860843],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002056669,"threshold_uncertainty_score":0.006461263,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02003089869661107,"score_gpt":0.2250340578338202,"score_spread":0.2050031591372092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}