{"id":"W3199804663","doi":"10.2139/ssrn.3517409","title":"Ileo-Colonic Delivery of Conjugated Bile Acids Improves Glucose Homeostasis <i>via</i> Colonic GLP-1-Producing Enteroendocrine Cells in Human Obesity and Diabetes","year":2020,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Trinity College","funders":"","keywords":"Enteroendocrine cell; Glucose homeostasis; Internal medicine; Endocrinology; Homeostasis; Medicine; Glucagon-like peptide-1; Diabetes mellitus; Endocrine system; Type 2 diabetes; Chemistry; Insulin resistance; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002852301,0.000514491,0.0007745274,0.000280997,0.0003008793,0.0006043956,0.0002712193,0.0006697084,0.002355229],"category_scores_gemma":[0.0002317938,0.0002803211,0.0004582819,0.0002608429,0.0006962167,0.0006957949,0.0003109127,0.002199243,0.0006103776],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003568555,"about_ca_system_score_gemma":0.0006090695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001507265,"about_ca_topic_score_gemma":0.002697274,"domain_scores_codex":[0.9997595,0.00005520437,0.00002426185,0.00004619339,0.00003108721,0.00008370837],"domain_scores_gemma":[0.9997939,0.00003086725,0.00004288764,0.00002461881,0.00001792973,0.0000897904],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0153163,0.00121542,0.0002145005,0.0001673813,0.00003375488,0.0001263047,0.00008824104,0.0003088592,0.9720968,0.0002364213,0.0003000042,0.009896184],"study_design_scores_gemma":[0.001363757,0.01345008,0.003124242,0.0000316159,0.0001304245,0.0001622167,0.0002580133,0.001157456,0.9758447,0.0001123255,0.004340459,0.00002481982],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950894,0.001228056,0.001136258,0.0005270554,0.0002389092,0.00004025765,0.0002055845,0.0001089494,0.001425571],"genre_scores_gemma":[0.993743,0.0009493024,0.001203181,0.0001809498,0.00004031018,0.0000390287,0.0002380871,0.00004691924,0.003559353],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002355229,"threshold_uncertainty_score":0.007878959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006889431027573604,"score_gpt":0.2173041694512992,"score_spread":0.2104147384237255,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}