{"id":"W3199851388","doi":"10.1016/j.chembiol.2021.07.017","title":"Clionamines stimulate autophagy, inhibit Mycobacterium tuberculosis survival in macrophages, and target Pik1","year":2021,"lang":"en","type":"article","venue":"Cell chemical biology","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto; University of British Columbia","funders":"Canadian Institutes of Health Research; Ontario Ministry of Research and Innovation; RIKEN; Natural Sciences and Engineering Research Council of Canada; Ontario Ministry of Research, Innovation and Science; Ministry of Education, Culture, Sports, Science and Technology; Canada Foundation for Innovation","keywords":"Autophagy; Mycobacterium tuberculosis; Biology; Small interfering RNA; Innate immune system; Biotinylation; Cell biology; Yeast; Saccharomyces cerevisiae; Phagosome; Microbiology; Tuberculosis; Immune system; RNA; Biochemistry; Gene; Phagocytosis; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009372225,0.0002058358,0.0004573093,0.00006341421,0.00002685971,0.00001058233,0.00006617744,0.0002888261,0.0007060596],"category_scores_gemma":[0.00007771298,0.0001796138,0.00009329775,0.0002030591,0.0001763397,0.00003331784,0.0001239737,0.0002517514,0.00004386386],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004225375,"about_ca_system_score_gemma":0.00007762115,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002009764,"about_ca_topic_score_gemma":0.000001581682,"domain_scores_codex":[0.9987094,0.00007863159,0.0003060853,0.0004717234,0.00007951827,0.0003546904],"domain_scores_gemma":[0.9993101,0.0001350321,0.000045973,0.0002476019,0.00006587167,0.000195395],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001791891,0.0002919846,0.02682144,0.0001090198,0.00004291887,0.0003596723,0.00005088102,7.714439e-7,0.9709677,0.0001549604,0.0001254297,0.0008960336],"study_design_scores_gemma":[0.002450947,0.00009636611,0.03292137,0.00003337653,0.00004571403,0.00006201397,0.00002686393,0.0001285709,0.9596003,0.001344046,0.003087584,0.0002028578],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909503,0.0064691,0.00001523057,0.0005629154,0.0002156885,0.000130488,0.00004143065,0.00005311377,0.00156168],"genre_scores_gemma":[0.9967564,0.0007239924,0.0005338,0.0009079319,0.0002110098,0.00001515406,0.0003701287,0.00002341523,0.0004581276],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0113674,"threshold_uncertainty_score":0.7730858,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01033774996665653,"score_gpt":0.2627608339610778,"score_spread":0.2524230839944213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}