{"id":"W3199851388","doi":"10.1016/j.chembiol.2021.07.017","title":"Clionamines stimulate autophagy, inhibit Mycobacterium tuberculosis survival in macrophages, and target Pik1","year":2021,"lang":"en","type":"article","venue":"Cell chemical biology","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto; University of British Columbia","funders":"Canadian Institutes of Health Research; Ontario Ministry of Research and Innovation; RIKEN; Natural Sciences and Engineering Research Council of Canada; Ontario Ministry of Research, Innovation and Science; Ministry of Education, Culture, Sports, Science and Technology; Canada Foundation for Innovation","keywords":"Autophagy; Mycobacterium tuberculosis; Biology; Small interfering RNA; Innate immune system; Biotinylation; Cell biology; Yeast; Saccharomyces cerevisiae; Phagosome; Microbiology; Tuberculosis; Immune system; RNA; Biochemistry; Gene; Phagocytosis; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009726638,0.0002514945,0.0002349373,0.0001865003,0.0002023049,0.0004285884,0.0002245157,0.0003782957,0.003596751],"category_scores_gemma":[0.0001195362,0.0001300089,0.0003663518,0.0001256533,0.000189518,0.000195951,0.0003298007,0.0005889811,0.0006678651],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003386292,"about_ca_system_score_gemma":0.0003526063,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009463708,"about_ca_topic_score_gemma":0.003521207,"domain_scores_codex":[0.9998888,0.00001477604,0.00001223101,0.00001697302,0.00002169144,0.00004553579],"domain_scores_gemma":[0.9999316,0.000009294551,0.00001941127,0.000009787071,0.00001109105,0.00001881428],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001910241,0.0001264702,0.0005853517,0.0002668774,0.0000455785,0.00010635,0.00002841923,0.0001622549,0.988746,0.0003159753,0.0009527869,0.00675355],"study_design_scores_gemma":[0.0001670678,0.0008685151,0.005744853,0.0000294556,0.00004190742,0.0002230986,0.00006604989,0.0005635935,0.9799469,0.0001164814,0.01222218,0.00000994821],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9741145,0.01061044,0.002342125,0.0009424937,0.0003909705,0.00008717551,0.001875296,0.0002502345,0.009386715],"genre_scores_gemma":[0.9882376,0.002402113,0.001033852,0.0002946713,0.00005015394,0.00004550374,0.0007795423,0.00002076731,0.007135849],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003596751,"threshold_uncertainty_score":0.01203233,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01033774996665653,"score_gpt":0.2627608339610778,"score_spread":0.2524230839944213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}