{"id":"W3199885424","doi":"10.3390/pharmaceutics13091466","title":"Contribution of CYP2D6 Functional Activity to Oxycodone Efficacy in Pain Management: Genetic Polymorphisms, Phenoconversion, and Tissue-Selective Metabolism","year":2021,"lang":"en","type":"review","venue":"Pharmaceutics","topic":"Pain Management and Opioid Use","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Oxymorphone; Oxycodone; CYP2D6; Pharmacology; Opioid; Pharmacogenomics; Medicine; Pharmacogenetics; Analgesic; Internal medicine; Biology; Receptor; Cytochrome P450; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001136915,0.0003255212,0.0009164333,0.0008962909,0.000136152,0.0008858888,0.0003802438,0.0004685893,0.002024873],"category_scores_gemma":[0.002407133,0.0001425671,0.001277047,0.001785544,0.0003518851,0.0004556244,0.0002582661,0.0006600545,0.0003561248],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003680979,"about_ca_system_score_gemma":0.0005473875,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001380024,"about_ca_topic_score_gemma":0.001481246,"domain_scores_codex":[0.9992888,0.000187332,0.0001709109,0.0001362356,0.0001717187,0.00004485508],"domain_scores_gemma":[0.998477,0.0009842061,0.0002831116,0.00004460332,0.0001806343,0.00003031922],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001389467,0.0001036844,0.07611682,0.03293225,0.00390277,0.002456904,0.0002740823,0.0009236289,0.007663213,0.003074457,0.01149163,0.8596711],"study_design_scores_gemma":[0.0004069821,0.001096346,0.3955705,0.0109802,0.01731718,0.03097114,0.0004332108,0.001907652,0.01371322,0.007491342,0.519916,0.0001961752],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01212854,0.9837266,0.00110399,0.000890031,0.0001656516,0.00001702042,0.0004123954,0.00001441565,0.00154141],"genre_scores_gemma":[0.09999119,0.8952422,0.001282536,0.0009147864,0.0006207438,0.00003375012,0.0009385165,0.00001406372,0.0009622114],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002024873,"threshold_uncertainty_score":0.006773829,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05938009816226725,"score_gpt":0.3615267588934403,"score_spread":0.3021466607311731,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}