{"id":"W3199905756","doi":"10.1002/mds.28787","title":"Coding and Noncoding Variation in <scp><i>LRRK2</i></scp> and Parkinson's Disease Risk","year":2021,"lang":"en","type":"review","venue":"Movement Disorders","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Institute of Genetics; National Institute of Environmental Health Sciences; National Institute of Neurological Disorders and Stroke; National Cancer Institute; National Institute for Health and Care Research; National Institute on Aging; Medical Research Council Canada; Medical Research Council; Michael J. Fox Foundation for Parkinson's Research; Parkinson Vereniging; Assistance publique-Hôpitaux de Paris; Parkinson's UK; Multiple System Atrophy Coalition; Agence Nationale de la Recherche; Wellcome Trust; Deutsche Forschungsgemeinschaft; Helsingin ja Uudenmaan Sairaanhoitopiiri; Helsingin Yliopisto; Fondation de France; Bundesministerium für Bildung und Forschung; EU Joint Programme – Neurodegenerative Disease Research; American Parkinson Disease Association; Idorsia Pharmaceuticals; U.S. Department of Defense; Itä-Suomen Yliopisto; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"LRRK2; Genome-wide association study; Genetic association; Linkage disequilibrium; Genetics; Biology; Allele; Disease; Haplotype; Gene; Medicine; Bioinformatics; Genotype; Internal medicine; Single-nucleotide polymorphism; Mutation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00305665,0.0008205011,0.001468371,0.001307712,0.0004564919,0.001162025,0.0007383986,0.0007987409,0.001649972],"category_scores_gemma":[0.005019406,0.000333806,0.007561906,0.002927262,0.000387477,0.0003108641,0.0004618257,0.0007114846,0.0001741146],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000372289,"about_ca_system_score_gemma":0.0003945048,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004935313,"about_ca_topic_score_gemma":0.006136254,"domain_scores_codex":[0.9974323,0.001019263,0.0003934909,0.0007381301,0.0002913563,0.0001255588],"domain_scores_gemma":[0.9956397,0.002862726,0.0007807232,0.0003880003,0.0001963613,0.0001324883],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.009218554,0.00007065529,0.6991798,0.00308438,0.253599,0.001110183,0.0001593004,0.00316066,0.00810986,0.0005990567,0.001223582,0.02048496],"study_design_scores_gemma":[0.00119826,0.0007696933,0.6767785,0.0007300004,0.3065574,0.001621611,0.0001290581,0.003900192,0.003054415,0.001461469,0.003751946,0.0000474303],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.8849645,0.1028912,0.005573143,0.0009075847,0.0003988826,0.00006721771,0.003038377,0.0001130994,0.002046028],"genre_scores_gemma":[0.9940779,0.003965565,0.0007250418,0.0001800241,0.0001040442,0.00003029251,0.0007252375,0.00001838322,0.0001734544],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.004935313,"threshold_uncertainty_score":0.01616526,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0209738954266663,"score_gpt":0.2854621116312655,"score_spread":0.2644882162045992,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}