{"id":"W3199905756","doi":"10.1002/mds.28787","title":"Coding and Noncoding Variation in <scp><i>LRRK2</i></scp> and Parkinson's Disease Risk","year":2021,"lang":"en","type":"review","venue":"Movement Disorders","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Institute of Genetics; National Institute of Environmental Health Sciences; National Institute of Neurological Disorders and Stroke; National Cancer Institute; National Institute for Health and Care Research; National Institute on Aging; Medical Research Council Canada; Medical Research Council; Michael J. Fox Foundation for Parkinson's Research; Parkinson Vereniging; Assistance publique-Hôpitaux de Paris; Parkinson's UK; Multiple System Atrophy Coalition; Agence Nationale de la Recherche; Wellcome Trust; Deutsche Forschungsgemeinschaft; Helsingin ja Uudenmaan Sairaanhoitopiiri; Helsingin Yliopisto; Fondation de France; Bundesministerium für Bildung und Forschung; EU Joint Programme – Neurodegenerative Disease Research; American Parkinson Disease Association; Idorsia Pharmaceuticals; U.S. Department of Defense; Itä-Suomen Yliopisto; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"LRRK2; Genome-wide association study; Genetic association; Linkage disequilibrium; Genetics; Biology; Allele; Disease; Haplotype; Gene; Medicine; Bioinformatics; Genotype; Internal medicine; Single-nucleotide polymorphism; Mutation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003233872,0.000556547,0.001318018,0.0003353285,0.0001696649,0.00009890378,0.00007529224,0.0001814565,0.00002997153],"category_scores_gemma":[0.0003189664,0.000501297,0.0002597496,0.0003378678,0.00004832929,0.0001110681,0.0001555773,0.0003078343,0.000007607091],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002487027,"about_ca_system_score_gemma":0.0002222444,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001579563,"about_ca_topic_score_gemma":0.00008287145,"domain_scores_codex":[0.9975739,0.0002065718,0.0005026368,0.000912751,0.0003564568,0.0004476492],"domain_scores_gemma":[0.9985576,0.000288083,0.0003324591,0.000369873,0.00002802389,0.0004239872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001706279,0.0006846379,0.02206116,0.01031594,0.0007500075,0.0003183525,0.0002857111,0.000002316281,0.000001692184,0.000738388,0.000538121,0.9642866],"study_design_scores_gemma":[0.00248919,0.0001093495,0.02442389,0.009821397,0.003479616,0.000001826832,0.0002629517,0.0002353848,8.005421e-7,0.00212393,0.9567975,0.000254147],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00412757,0.9931832,0.0002736189,0.00009685405,0.0001789392,0.00146773,0.0001767799,0.00004797137,0.0004473256],"genre_scores_gemma":[0.002530434,0.9956301,0.000347019,0.0003986804,0.00006732104,0.00036935,0.00034058,0.00007648241,0.0002400345],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9640325,"threshold_uncertainty_score":0.9997439,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0209738954266663,"score_gpt":0.2854621116312655,"score_spread":0.2644882162045992,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}