{"id":"W3199917877","doi":"10.1182/blood.2021013244","title":"Metabolomic identification of α-ketoglutaric acid elevation in pediatric chronic graft-versus-host disease","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; CancerCare Manitoba; Centre Hospitalier Universitaire Sainte-Justine; Alberta Children's Hospital; University of Calgary; SickKids Foundation; University of Toronto; BC Children's Hospital; Hospital for Sick Children; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Internal medicine; Medicine; Graft-versus-host disease; Hematopoietic stem cell transplantation; Biomarker; Metabolomics; Disease; Immunology; Gastroenterology; Oncology; Biology; Bioinformatics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002556903,0.0002603738,0.0003719419,0.00066815,0.0001455483,0.0004010673,0.000109175,0.0002127125,0.0004272103],"category_scores_gemma":[0.0005440478,0.0001203096,0.0002151321,0.0008069401,0.0001229124,0.0001592524,0.0002502161,0.0002238114,0.00007914136],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001704937,"about_ca_system_score_gemma":0.0001370755,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001205644,"about_ca_topic_score_gemma":0.001384186,"domain_scores_codex":[0.9998595,0.00003568071,0.00001088178,0.00004263333,0.00003015188,0.00002116394],"domain_scores_gemma":[0.9997428,0.00004497066,0.0001100194,0.00002067805,0.00004071437,0.0000408179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001911173,0.00007056985,0.9049139,0.00008225758,0.000171082,0.0002817254,0.0001278429,0.0003486226,0.07755756,0.00003598208,0.0001203516,0.01437895],"study_design_scores_gemma":[0.000007384515,0.0004452532,0.9929265,0.000005844122,0.00006075787,0.0004524107,0.00007139854,0.0003383603,0.00531569,0.00003018647,0.0003414798,0.000004613458],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982092,0.0006831836,0.0003386547,0.00001431632,0.000002244957,0.000007707454,0.00061519,0.000007465122,0.0001219308],"genre_scores_gemma":[0.9980816,0.0003298911,0.0006841837,0.00002492604,0.000004578428,0.00001093165,0.0007559715,0.000004773005,0.0001032877],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001205644,"threshold_uncertainty_score":0.002397239,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01437286469196142,"score_gpt":0.2603566810486302,"score_spread":0.2459838163566688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}