{"id":"W3199921626","doi":"10.1016/j.molcel.2021.08.028","title":"A hydride transfer complex reprograms NAD metabolism and bypasses senescence","year":2021,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hôpital Maisonneuve-Rosemont; Jewish General Hospital; Université de Montréal; Institute for Research in Immunology and Cancer; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"Fonds de Recherche du Québec - Santé; National Foundation for Science and Technology Development; Canadian Cancer Society Research Institute; Steirische Wirtschaftsförderungsgesellschaft; Canadian Institutes of Health Research; Institut Du Cancer de Montréal; Bundesministerium für Digitalisierung und Wirtschaftsstandort; Natural Sciences and Engineering Research Council of Canada; Bundesministerium für Verkehr, Innovation und Technologie; Österreichischen Akademie der Wissenschaften; Terry Fox Research Institute; Canadian Imperial Bank of Commerce","keywords":"Biology; Senescence; NAD+ kinase; Cancer cell; Cell biology; Cytosol; Carcinogenesis; Malic enzyme; Biochemistry; Enzyme; Cancer; Dehydrogenase; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000114499,0.0001551351,0.0001487407,0.00002188019,0.00006566231,0.00005395972,0.00008786142,0.0001181234,0.00002214446],"category_scores_gemma":[0.00003332848,0.0001631687,0.0000918213,0.0001070305,0.00005967127,0.000002590764,0.00007421063,0.00007014613,0.000005246913],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003857193,"about_ca_system_score_gemma":0.00005109501,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002439177,"about_ca_topic_score_gemma":0.00002870553,"domain_scores_codex":[0.9988979,0.00009779973,0.0001725669,0.0004706598,0.0001398111,0.0002212249],"domain_scores_gemma":[0.9993692,0.000007112046,0.00002501954,0.0003896155,0.0001033775,0.0001056731],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001013462,0.00005393952,0.0006023041,0.0000215357,0.00002260721,0.00004438787,0.00003043014,0.00004067642,0.9922132,0.0001129488,0.00003859565,0.006809161],"study_design_scores_gemma":[0.000379564,0.00004817366,0.001705836,0.000004382529,0.00003343656,0.000008199419,0.00002748509,0.00008575494,0.8831821,0.0001593774,0.1141816,0.0001840449],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9440862,0.01409622,0.03824614,0.0001844862,0.00007621775,0.0001216036,0.0000101789,0.00001422462,0.003164728],"genre_scores_gemma":[0.9932559,0.001023368,0.004690026,0.0003485213,0.00006368831,0.00001339218,0.0001762672,0.00002779217,0.0004010954],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.114143,"threshold_uncertainty_score":0.6653827,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01150838762762516,"score_gpt":0.2385303649658074,"score_spread":0.2270219773381823,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}