{"id":"W3199921626","doi":"10.1016/j.molcel.2021.08.028","title":"A hydride transfer complex reprograms NAD metabolism and bypasses senescence","year":2021,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hôpital Maisonneuve-Rosemont; Jewish General Hospital; Université de Montréal; Institute for Research in Immunology and Cancer; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"Fonds de Recherche du Québec - Santé; National Foundation for Science and Technology Development; Canadian Cancer Society Research Institute; Steirische Wirtschaftsförderungsgesellschaft; Canadian Institutes of Health Research; Institut Du Cancer de Montréal; Bundesministerium für Digitalisierung und Wirtschaftsstandort; Natural Sciences and Engineering Research Council of Canada; Bundesministerium für Verkehr, Innovation und Technologie; Österreichischen Akademie der Wissenschaften; Terry Fox Research Institute; Canadian Imperial Bank of Commerce","keywords":"Biology; Senescence; NAD+ kinase; Cancer cell; Cell biology; Cytosol; Carcinogenesis; Malic enzyme; Biochemistry; Enzyme; Cancer; Dehydrogenase; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002519253,0.0003789179,0.0003833152,0.0002847315,0.0002752723,0.0005408822,0.0004786825,0.0006343002,0.002259217],"category_scores_gemma":[0.0003429799,0.0002498807,0.0002964847,0.0001349768,0.000576982,0.000330622,0.000627189,0.0007502482,0.0004642126],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005890563,"about_ca_system_score_gemma":0.0003633046,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008107133,"about_ca_topic_score_gemma":0.0008664655,"domain_scores_codex":[0.9998246,0.00002735775,0.00001246896,0.00005134869,0.00004196009,0.00004227185],"domain_scores_gemma":[0.9997332,0.00005035629,0.00005451027,0.00005988192,0.00001835905,0.00008373156],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003122215,0.0000218758,0.00008185354,0.00001551755,0.00001078135,0.00005189459,0.00001110898,0.00005463459,0.9981352,0.0004017284,0.00008444009,0.0008187025],"study_design_scores_gemma":[0.00002409265,0.00008271561,0.0005675312,0.000001223361,0.000006221082,0.00009205338,0.00001086515,0.0003565012,0.9975867,0.0000897384,0.00117769,0.000004646534],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855528,0.00072281,0.009083235,0.0004477807,0.0002181928,0.00006302004,0.0003917434,0.0009100336,0.002610349],"genre_scores_gemma":[0.995584,0.0001582543,0.001649761,0.00005497412,0.00001840445,0.00001387955,0.0002136738,0.00006927703,0.002237904],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002259217,"threshold_uncertainty_score":0.007557869,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01150838762762516,"score_gpt":0.2385303649658074,"score_spread":0.2270219773381823,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}