{"id":"W3199957122","doi":"10.1158/1535-7163.mct-20-0144","title":"Targeting the IGF-Axis Potentiates Immunotherapy for Pancreatic Ductal Adenocarcinoma Liver Metastases by Altering the Immunosuppressive Microenvironment","year":2021,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"National Cancer Institute; Canadian Institute for Military and Veteran Health Research; Mitacs","keywords":"Cancer research; Immunotherapy; Tumor microenvironment; Medicine; Blockade; Metastasis; Immune system; Pancreatic cancer; Immunology; Biology; Cancer; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009027824,0.0003653675,0.0002736846,0.0001765289,0.0000871564,0.0001915419,0.0001234783,0.0001561668,0.0006741407],"category_scores_gemma":[0.0000494045,0.00005176514,0.0001381807,0.00008243661,0.000165891,0.0001323145,0.0001469963,0.0006615042,0.0001191899],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001286737,"about_ca_system_score_gemma":0.0001876601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002471341,"about_ca_topic_score_gemma":0.0008576942,"domain_scores_codex":[0.9999332,0.00001297511,0.000003920522,0.000009101867,0.00001568109,0.00002494976],"domain_scores_gemma":[0.9999661,0.000006036971,0.000008650159,0.000002636884,0.000002385509,0.00001406637],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005805717,0.000373976,0.000247583,0.00007845472,0.00001114881,0.00005356641,0.00001477031,0.000433144,0.9856697,0.0001386498,0.0001194231,0.01227906],"study_design_scores_gemma":[0.0002048932,0.008098283,0.004860109,0.00001404366,0.00007212422,0.000384402,0.00003043961,0.002233439,0.9795313,0.0001075217,0.004454073,0.000009341141],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948992,0.001730165,0.001382439,0.0001311701,0.00006477883,0.00004486633,0.00008827759,0.00007077837,0.001588309],"genre_scores_gemma":[0.9969626,0.0009103962,0.00102696,0.00004854722,0.00003343259,0.00002638306,0.00007646572,0.000006136354,0.0009091832],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006741407,"threshold_uncertainty_score":0.002255201,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02497956645918837,"score_gpt":0.3042864441328752,"score_spread":0.2793068776736868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}