{"id":"W3199985489","doi":"10.1093/noajnl/vdab112.032","title":"SYST-04. TRAM-01: A PHASE 2 STUDY OF TRAMETINIB FOR PATIENTS WITH PEDIATRIC GLIOMA WITH ACTIVATION OF THE MAPK/ERK PATHWAY","year":2021,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"IWK Foundation; BC Children's Hospital; Centre Hospitalier Universitaire de Sherbrooke; Hospital for Sick Children; Alberta Children's Hospital; Centre hospitalier de l'Université Laval; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Trametinib; Medicine; Tolerability; MAPK/ERK pathway; Internal medicine; Progressive disease; Oncology; Adverse effect; Progression-free survival; Gastroenterology; Surgery; Disease; Overall survival; Biology; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007449172,0.0001770907,0.0005039168,0.0001031128,0.00008000714,0.000004469299,0.00008700792,0.00006289394,0.00001452575],"category_scores_gemma":[0.0002874634,0.00009861978,0.00007894774,0.0005673302,0.00008014499,0.0000932002,0.00002229596,0.0001085119,3.968169e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004504577,"about_ca_system_score_gemma":0.0002183577,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006267217,"about_ca_topic_score_gemma":0.00004462628,"domain_scores_codex":[0.9986738,0.0001311316,0.000348308,0.0003423298,0.0003108433,0.0001936157],"domain_scores_gemma":[0.9980875,0.0007552193,0.0004259886,0.0003209112,0.000348721,0.0000617227],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007529348,0.04980912,0.8854013,0.0005006726,0.0003724369,0.0002286873,0.001432991,0.0002027098,0.02508065,0.00008788584,0.00009845025,0.02925576],"study_design_scores_gemma":[0.09156501,0.09921744,0.4173564,0.0001922669,0.002040187,0.0001006473,0.003529073,0.00002903464,0.3819322,0.0000653847,0.003672927,0.000299441],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970574,0.0002236723,0.00003012437,0.0002733405,0.000160888,0.002092508,0.00004970646,0.00001677126,0.00009560429],"genre_scores_gemma":[0.9987599,0.00002665101,0.0006214998,0.00008388844,0.00005683064,0.000400187,0.00002335043,0.00002249339,0.000005151965],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4680449,"threshold_uncertainty_score":0.4021598,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01392361391372867,"score_gpt":0.2940159042242949,"score_spread":0.2800922903105663,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}