{"id":"W3199985489","doi":"10.1093/noajnl/vdab112.032","title":"SYST-04. TRAM-01: A PHASE 2 STUDY OF TRAMETINIB FOR PATIENTS WITH PEDIATRIC GLIOMA WITH ACTIVATION OF THE MAPK/ERK PATHWAY","year":2021,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"IWK Foundation; BC Children's Hospital; Centre Hospitalier Universitaire de Sherbrooke; Hospital for Sick Children; Alberta Children's Hospital; Centre hospitalier de l'Université Laval; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Trametinib; Medicine; Tolerability; MAPK/ERK pathway; Internal medicine; Progressive disease; Oncology; Adverse effect; Progression-free survival; Gastroenterology; Surgery; Disease; Overall survival; Biology; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001591383,0.001262643,0.00134065,0.0004760859,0.0002857276,0.0008880291,0.0007950106,0.0009876997,0.002641758],"category_scores_gemma":[0.0005478768,0.0004702413,0.001004819,0.0004419876,0.0006079426,0.0005973894,0.0002780445,0.002266237,0.0006970675],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001244711,"about_ca_system_score_gemma":0.002241139,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001700115,"about_ca_topic_score_gemma":0.005156789,"domain_scores_codex":[0.9996827,0.0001594225,0.00001538196,0.00004200882,0.00002801876,0.00007253913],"domain_scores_gemma":[0.9995827,0.00005536331,0.00007560515,0.00002058008,0.0000291144,0.0002367042],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5135666,0.08422316,0.02610165,0.002417973,0.002815518,0.001227027,0.0007992503,0.006060753,0.1010028,0.001159714,0.01667584,0.2439497],"study_design_scores_gemma":[0.5400416,0.4167574,0.025804,0.00007162238,0.0008919507,0.001025068,0.00008602329,0.002702166,0.006035321,0.0001954558,0.006339779,0.00004967207],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908506,0.003101294,0.0004286256,0.0006221781,0.0000752218,0.001383047,0.001885434,0.0001313793,0.001522219],"genre_scores_gemma":[0.98301,0.003362918,0.002639047,0.001053756,0.0001375024,0.002452759,0.004430756,0.00003717935,0.00287615],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002641758,"threshold_uncertainty_score":0.009031057,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01392361391372867,"score_gpt":0.2940159042242949,"score_spread":0.2800922903105663,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}