{"id":"W3200114420","doi":"10.3390/cancers13184699","title":"Metabolic Flexibility Is a Determinant of Breast Cancer Heterogeneity and Progression","year":2021,"lang":"en","type":"review","venue":"Cancers","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Institute for Research in Immunology and Cancer; Université de Montréal; McGill University Health Centre","funders":"Fonds de Recherche du Québec - Santé; Génome Québec; Canadian Institutes of Health Research; Cancer Research Society; McGill University","keywords":"Breast cancer; Metabolic adaptation; Breast tumours; Tumour heterogeneity; Epigenetics; Flexibility (engineering); Biology; Metabolic pathway; Cancer; Cancer research; Bioinformatics; Medicine; Metabolism; Endocrinology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003250479,0.0005315127,0.000947959,0.001206174,0.0002171066,0.001054147,0.0005171995,0.0008529912,0.002997076],"category_scores_gemma":[0.0004702216,0.000209308,0.000384857,0.001024211,0.0003546733,0.0007778376,0.0005785826,0.001283023,0.001411871],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007038926,"about_ca_system_score_gemma":0.0007458687,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001178094,"about_ca_topic_score_gemma":0.001780352,"domain_scores_codex":[0.9998754,0.00002222249,0.00001421209,0.00002644766,0.00004153038,0.00002026952],"domain_scores_gemma":[0.9998434,0.00006339881,0.00002523666,0.000004594355,0.00004592819,0.00001747004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001256417,0.00004954158,0.0005239822,0.01589286,0.0001142215,0.0003406054,0.00006876174,0.0006094695,0.005723482,0.008137133,0.02803807,0.9403763],"study_design_scores_gemma":[0.00001019703,0.0001090331,0.002053165,0.002408062,0.0001175001,0.001900093,0.00006764322,0.0001790668,0.002274619,0.003326303,0.9875259,0.0000282769],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002520394,0.9979631,0.000172056,0.0003609055,0.000129038,0.000003575973,0.00003017666,0.000008230117,0.001080933],"genre_scores_gemma":[0.001639461,0.9973726,0.0001095107,0.000125405,0.00009606979,0.000005044544,0.00004498988,0.000001706917,0.0006052454],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002997076,"threshold_uncertainty_score":0.01002622,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03419096911846098,"score_gpt":0.3661180425991257,"score_spread":0.3319270734806647,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}