{"id":"W3200137096","doi":"10.1128/aac.00772-21","title":"The Natural Stilbenoid (–)-Hopeaphenol Inhibits Cellular Entry of SARS-CoV-2 USA-WA1/2020, B.1.1.7, and B.1.351 Variants","year":2021,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Australian Research Council; Canadian Institutes of Health Research; National Health and Medical Research Council; Government of Canada","keywords":"Cytotoxicity; Viral entry; Cytopathic effect; Viral replication; Cell culture; Small molecule; Enzyme; Binding site; In vitro; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008146159,0.0002271438,0.0001347438,0.0001152352,0.00007666297,0.0001854383,0.0001161444,0.0001809649,0.001599677],"category_scores_gemma":[0.00006447104,0.00006185276,0.0001738134,0.0001079013,0.0001187892,0.0001380192,0.00009302184,0.0004288737,0.0003225623],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001677642,"about_ca_system_score_gemma":0.0001535683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001064397,"about_ca_topic_score_gemma":0.002780264,"domain_scores_codex":[0.9999439,0.00001033993,0.000005595858,0.0000109424,0.0000140729,0.00001520559],"domain_scores_gemma":[0.9999715,0.000005878789,0.000007227235,0.000003711289,0.000003799851,0.00000784568],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000211455,0.00004450932,0.0001402194,0.0000350495,0.000005676351,0.0000144318,0.000009594481,0.00004790392,0.997668,0.00004461344,0.00006310359,0.001715483],"study_design_scores_gemma":[0.00003108868,0.001609957,0.0054277,0.000008880507,0.00001702872,0.0001617179,0.00005335933,0.0003871497,0.9885317,0.00004265262,0.003722237,0.000006401785],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932545,0.002481437,0.0007538211,0.00009254547,0.00004205334,0.00002999227,0.000723952,0.00004288073,0.002578828],"genre_scores_gemma":[0.9926426,0.00140843,0.001343194,0.00008107816,0.000009984466,0.00001418881,0.001181979,0.000007948142,0.003310604],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001599677,"threshold_uncertainty_score":0.005351424,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01297426169044214,"score_gpt":0.2633314964003804,"score_spread":0.2503572347099383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}