{"id":"W3200167435","doi":"10.1021/acschembio.1c00456","title":"Deorphanizing Caspase-3 and Caspase-9 Substrates In and Out of Apoptosis with Deep Substrate Profiling","year":2021,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":146,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Alberta Innovates","keywords":"Caspase; Proteases; Proteolysis; NLRP1; Caspase 2; Cell biology; Caspase 10; Cytochrome c; Caspase 3; Apoptosis; Caspase 8; Biology; Caspase 1; Programmed cell death; Caspase-9; Chemistry; Biochemistry; Mitochondrion; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008145256,0.000118723,0.0001788306,0.00002482814,0.00002257319,0.000008301725,0.0000422165,0.000207134,0.000004295744],"category_scores_gemma":[0.00003785807,0.00009831732,0.0000194045,0.0000661907,0.0001244095,0.00000329867,0.00006781215,0.00007308771,2.940357e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005192123,"about_ca_system_score_gemma":0.00003229215,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002002014,"about_ca_topic_score_gemma":0.0001162691,"domain_scores_codex":[0.9992509,0.00003279044,0.0001771365,0.0003266985,0.00003340786,0.0001790343],"domain_scores_gemma":[0.9996752,0.00002536724,0.00005978386,0.000124611,0.00006197557,0.00005305555],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005923578,0.0000269348,0.01145076,0.00003286691,0.00002334269,0.000005790417,0.00004788644,0.000003992452,0.986371,0.0004327504,0.000001277241,0.001544134],"study_design_scores_gemma":[0.0005228588,0.000111148,0.001029689,0.0000159841,0.00001447469,0.00004129037,0.0001846356,0.00005990819,0.9974557,0.0003915429,0.00004697481,0.000125749],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997548,0.001935343,0.0002421501,0.00006326741,0.00002946965,0.00008259605,0.000007773207,0.000004508911,0.00008689112],"genre_scores_gemma":[0.9969954,0.0005336123,0.002159707,0.00004218934,0.00003934148,0.000008793049,0.0001923994,0.00001064857,0.00001788176],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01108471,"threshold_uncertainty_score":0.4009264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01046998993301013,"score_gpt":0.231887720524865,"score_spread":0.2214177305918548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}