{"id":"W3200167435","doi":"10.1021/acschembio.1c00456","title":"Deorphanizing Caspase-3 and Caspase-9 Substrates In and Out of Apoptosis with Deep Substrate Profiling","year":2021,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":146,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Alberta Innovates","keywords":"Caspase; Proteases; Proteolysis; NLRP1; Caspase 2; Cell biology; Caspase 10; Cytochrome c; Caspase 3; Apoptosis; Caspase 8; Biology; Caspase 1; Programmed cell death; Caspase-9; Chemistry; Biochemistry; Mitochondrion; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002595801,0.0005669459,0.0003115917,0.00031018,0.0001672579,0.0005489455,0.0002671342,0.000366592,0.0007892295],"category_scores_gemma":[0.0003343003,0.0002370157,0.0002687346,0.0002778643,0.0002464419,0.00056149,0.000456045,0.001008899,0.000483999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002967734,"about_ca_system_score_gemma":0.0002114571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002115021,"about_ca_topic_score_gemma":0.0005906048,"domain_scores_codex":[0.9997974,0.00002451738,0.00001038533,0.00005311195,0.00007456225,0.00004006062],"domain_scores_gemma":[0.9998577,0.00002711537,0.00003987637,0.00002400463,0.00002931697,0.00002197674],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005623711,0.0000107104,0.0002973011,0.00005070459,0.000007284194,0.00003763244,0.00001602689,0.000210536,0.9948822,0.0002354018,0.00009046849,0.004105547],"study_design_scores_gemma":[0.000006138295,0.00007656083,0.001972243,0.00000576475,0.00001344581,0.0002691117,0.00001781068,0.002824241,0.9913352,0.0004061616,0.003064949,0.000008384287],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9019042,0.003279382,0.08903036,0.0002386488,0.00007460045,0.00008367604,0.001315749,0.0004369657,0.003636352],"genre_scores_gemma":[0.9168908,0.004088573,0.07038008,0.0002873225,0.00003038222,0.0001298552,0.002616885,0.0001773336,0.005398848],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007892295,"threshold_uncertainty_score":0.002640247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01046998993301013,"score_gpt":0.231887720524865,"score_spread":0.2214177305918548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}