{"id":"W3200180651","doi":"10.1002/jcp.30588","title":"LRRK2 and WAVE2 regulate microglial‐transition through distinct morphological phenotypes to induce neurotoxicity in a novel two‐hit in vitro model of neurodegeneration","year":2021,"lang":"en","type":"article","venue":"Journal of Cellular Physiology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"Canadian Institutes of Health Research","keywords":"Microglia; Neurotoxicity; Cell biology; Neurodegeneration; Biology; Neuroinflammation; Inflammation; Chemistry; Immunology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004393742,0.0008815709,0.0006779914,0.0004253885,0.0003441615,0.0005225373,0.0004859686,0.0006020599,0.0009836598],"category_scores_gemma":[0.0001204667,0.0003156971,0.0005949836,0.0002537779,0.0003142573,0.0003999584,0.0003462794,0.001325694,0.0005848703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003939385,"about_ca_system_score_gemma":0.0003206484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009511268,"about_ca_topic_score_gemma":0.002550314,"domain_scores_codex":[0.9994212,0.0001152765,0.00008449149,0.00009482509,0.0001728242,0.0001113042],"domain_scores_gemma":[0.9998112,0.0000334132,0.00005618989,0.00003333951,0.00002933947,0.00003653634],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001457859,0.0001035281,0.00009802894,0.00004965828,0.000007928302,0.00007035601,0.00002359737,0.00007449034,0.9988141,0.00007414864,0.00005319869,0.0004851804],"study_design_scores_gemma":[0.0000468315,0.001134919,0.002099347,0.000006420767,0.00003454114,0.0002908044,0.00003874915,0.001475675,0.9934448,0.00007005264,0.00134752,0.00001039212],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9768266,0.003399292,0.01554676,0.0003063059,0.0001571273,0.000187162,0.0007757285,0.0001896664,0.002611397],"genre_scores_gemma":[0.9706914,0.002626382,0.01634932,0.0002119542,0.00007220378,0.0006584103,0.001456422,0.00004716194,0.007886846],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009836598,"threshold_uncertainty_score":0.003290653,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02956513032140618,"score_gpt":0.2661441832879103,"score_spread":0.2365790529665041,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}