{"id":"W3200233427","doi":"10.21769/bioprotoc.4168","title":"Assessing the in vitro Binding Specificity of Histone Modification Reader Proteins Using Histone Peptide Arrays","year":2021,"lang":"en","type":"article","venue":"BIO-PROTOCOL","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Histone; Peptide; Biology; Recombinant DNA; Computational biology; Biochemistry; Molecular biology; Cell biology; DNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007282887,0.0008850477,0.0004563727,0.0004725737,0.0003290394,0.0005452187,0.0007392044,0.0005555906,0.004523332],"category_scores_gemma":[0.0007279859,0.0006330953,0.0004445798,0.0005426233,0.0002487947,0.0003378842,0.0003966357,0.001194414,0.002544654],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004575987,"about_ca_system_score_gemma":0.0002559659,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007034822,"about_ca_topic_score_gemma":0.002020879,"domain_scores_codex":[0.9992925,0.0001508131,0.00005374115,0.0001544138,0.0002304262,0.0001181978],"domain_scores_gemma":[0.9994926,0.0002311146,0.00005843514,0.00004799405,0.0001070021,0.00006289224],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002336416,0.0000126711,0.000052676,0.00003539894,0.0000048144,0.00001070216,0.000008035246,0.00008014426,0.9991776,0.00003940918,0.00006436738,0.0004908002],"study_design_scores_gemma":[0.000005188414,0.00007913865,0.0006173804,0.000005212,0.0000109967,0.00003560781,0.00001106681,0.0009380679,0.9967781,0.00003099456,0.001481811,0.000006382131],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.7317274,0.003317668,0.2478761,0.0004504618,0.0002214847,0.000628708,0.003628523,0.001516059,0.01063365],"genre_scores_gemma":[0.6546533,0.005765485,0.3006278,0.000703895,0.0000849217,0.001333958,0.01412648,0.0006542054,0.02204999],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.004523332,"threshold_uncertainty_score":0.01513207,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04577060268132886,"score_gpt":0.3593501632179117,"score_spread":0.3135795605365829,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}