{"id":"W3200247568","doi":"10.1039/d1ob01023a","title":"Radiofluorination of non-activated aromatic prosthetic groups for synthesis and evaluation of fluorine-18 labelled ghrelin(1–8) analogues","year":2021,"lang":"en","type":"article","venue":"Organic & Biomolecular Chemistry","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Western University","keywords":"Ghrelin; Chemistry; Amide; Peptide; In vivo; Radiosynthesis; Ligand (biochemistry); Stereochemistry; Serine; Growth hormone secretagogue receptor; Receptor; Peptide synthesis; Combinatorial chemistry; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005116796,0.00052267,0.000298627,0.0002043554,0.0001612834,0.0001694962,0.0003563386,0.0005062252,0.001613674],"category_scores_gemma":[0.0003496709,0.0001770697,0.0002537213,0.0001752693,0.0002672669,0.000310406,0.0002092872,0.0005514551,0.0005084373],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003763843,"about_ca_system_score_gemma":0.0002469711,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004677942,"about_ca_topic_score_gemma":0.0009441827,"domain_scores_codex":[0.9998358,0.00004101697,0.000009751849,0.00003151089,0.00002808185,0.00005369541],"domain_scores_gemma":[0.9998349,0.00004974261,0.00004156032,0.00001465854,0.0000351745,0.00002392207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002035248,0.00002710782,0.00005083493,0.00008868525,0.000005103284,0.0001474117,0.00005511999,0.0002709613,0.9965392,0.0002391927,0.00004527971,0.002327648],"study_design_scores_gemma":[0.00002749074,0.000729826,0.0004685974,0.000007725208,0.00001134197,0.0002918254,0.00001639482,0.0003159216,0.9949793,0.00003726005,0.003104855,0.000009297227],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.975573,0.002497993,0.01804312,0.0001111512,0.00004253354,0.0001658559,0.0002995145,0.0000875809,0.003179249],"genre_scores_gemma":[0.9710575,0.002666074,0.02131553,0.00008071765,0.00001989657,0.0001920844,0.0004939244,0.00004054607,0.004133719],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001613674,"threshold_uncertainty_score":0.005398273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.022764746506466,"score_gpt":0.271770367738656,"score_spread":0.24900562123219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}