{"id":"W3200252567","doi":"10.1007/s00775-021-01902-7","title":"Dual roles of tau R peptides on Cu(II)/(I)-mediated reactive oxygen species formation","year":2021,"lang":"en","type":"article","venue":"JBIC Journal of Biological Inorganic Chemistry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Trent University","funders":"National Institute of General Medical Sciences","keywords":"Chemistry; Reactive oxygen species; Peptide; Reducing agent; Hydrogen peroxide; Metal ions in aqueous solution; Metal; Protein aggregation; Biophysics; Biochemistry; Stereochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001642108,0.0001513952,0.0004140285,0.00003806712,0.00006759635,0.00001108916,0.00009169669,0.0001651509,0.0008143029],"category_scores_gemma":[0.0008297779,0.00009680165,0.0002077347,0.0001912557,0.0001419089,0.0000845493,0.00007945897,0.0003630171,0.00001524409],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001610086,"about_ca_system_score_gemma":0.0003198225,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001575949,"about_ca_topic_score_gemma":5.939269e-7,"domain_scores_codex":[0.9986953,0.00005134709,0.0004685363,0.0001505011,0.0004086002,0.0002257049],"domain_scores_gemma":[0.9985859,0.0001760607,0.0003425452,0.0001637006,0.0004651862,0.0002666303],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007861244,0.001208747,0.007853888,0.00007069064,0.001949828,0.000734639,0.0001359622,6.855834e-7,0.9857163,0.00001553722,0.001033939,0.0004936482],"study_design_scores_gemma":[0.001863066,0.0008888424,0.05449102,0.0002073884,0.0001968952,0.0008274767,0.001525111,0.000005832223,0.9393035,0.0002269851,0.000363889,0.0001000478],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946272,0.002499122,0.000005465653,0.0007185259,0.00002952058,0.00007328235,0.00005216534,0.00001202762,0.001982689],"genre_scores_gemma":[0.998351,0.0009353933,0.00008023759,0.00008120525,0.0002533399,0.000001892349,0.0001670972,0.000008318055,0.0001215545],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04663713,"threshold_uncertainty_score":0.8916046,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03584403108770236,"score_gpt":0.2922447098038922,"score_spread":0.2564006787161898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}