{"id":"W3200263151","doi":"10.1016/j.biopsych.2021.09.008","title":"Longitudinal Structural Brain Changes in Bipolar Disorder: A Multicenter Neuroimaging Study of 1232 Individuals by the ENIGMA Bipolar Disorder Working Group","year":2021,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Vancouver Coastal Health; Dalhousie University","funders":"Singapore Bioimaging Consortium; Departament de Salut, Generalitat de Catalunya; Horizon 2020; Helse Sør-Øst RHF; European Research Council; Allergan; National Institutes of Health; Horizon 2020 Framework Programme; Stiftelsen för Strategisk Forskning; Norges Forskningsråd; European Commission; Hjärnfonden; Vetenskapsrådet; Dainippon Sumitomo Pharma; Sunovion; H. Lundbeck A/S; University of New South Wales; Angelini Pharma; Sanofi; Centro de Investigación Biomédica en Red de Salud Mental; Deutsche Forschungsgemeinschaft; Nova Scotia Health Research Foundation; National Institute on Aging; Abbott Laboratories; Health Research Board; European Regional Development Fund; National Healthcare Group; Biogen; Canadian Institutes of Health Research; Cilag; Brain and Behavior Research Foundation","keywords":"Bipolar disorder; Neuroimaging; Magnetic resonance imaging; Mood; Psychology; Mood disorders; Cardiology; Medicine; Internal medicine; Longitudinal study; Neuroscience; Pathology; Psychiatry; Radiology; Anxiety","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001006556,0.0004878999,0.0006170827,0.0007697865,0.0007496875,0.0007305298,0.0004304126,0.0006354947,0.0006935277],"category_scores_gemma":[0.001176173,0.000669583,0.0004950744,0.001240758,0.0003017566,0.0004145488,0.0005185819,0.0004871076,0.0002664461],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004429372,"about_ca_system_score_gemma":0.0002191454,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01128425,"about_ca_topic_score_gemma":0.01663312,"domain_scores_codex":[0.9995918,0.0001176822,0.00004135362,0.0001398264,0.00005675856,0.00005264063],"domain_scores_gemma":[0.9992036,0.00006609649,0.0003642762,0.0001215681,0.0001158007,0.0001287495],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003540585,0.00004008205,0.9969649,0.00001228689,0.0002563394,0.000111299,0.000211017,0.00002772157,0.0006540614,0.00001116283,0.000265033,0.001092071],"study_design_scores_gemma":[0.00002594463,0.00005164072,0.999398,0.000005763947,0.00006897242,0.0001495889,0.000111005,0.00004123802,0.0000268115,0.000008385061,0.0001094282,0.000003126129],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988168,0.000299817,0.00005845592,0.00002496825,0.000004161684,0.000009614704,0.0006611217,0.000003070167,0.0001220869],"genre_scores_gemma":[0.9973506,0.0002362736,0.0001420182,0.00003983069,0.00001282321,0.00002769056,0.002055198,0.000005170848,0.0001303445],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01128425,"threshold_uncertainty_score":0.02243716,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0300757736983824,"score_gpt":0.2937839748082093,"score_spread":0.263708201109827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}