{"id":"W3200263151","doi":"10.1016/j.biopsych.2021.09.008","title":"Longitudinal Structural Brain Changes in Bipolar Disorder: A Multicenter Neuroimaging Study of 1232 Individuals by the ENIGMA Bipolar Disorder Working Group","year":2021,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Vancouver Coastal Health; Dalhousie University","funders":"Singapore Bioimaging Consortium; Departament de Salut, Generalitat de Catalunya; Horizon 2020; Helse Sør-Øst RHF; European Research Council; Allergan; National Institutes of Health; Horizon 2020 Framework Programme; Stiftelsen för Strategisk Forskning; Norges Forskningsråd; European Commission; Hjärnfonden; Vetenskapsrådet; Dainippon Sumitomo Pharma; Sunovion; H. Lundbeck A/S; University of New South Wales; Angelini Pharma; Sanofi; Centro de Investigación Biomédica en Red de Salud Mental; Deutsche Forschungsgemeinschaft; Nova Scotia Health Research Foundation; National Institute on Aging; Abbott Laboratories; Health Research Board; European Regional Development Fund; National Healthcare Group; Biogen; Canadian Institutes of Health Research; Cilag; Brain and Behavior Research Foundation","keywords":"Bipolar disorder; Neuroimaging; Magnetic resonance imaging; Mood; Psychology; Mood disorders; Cardiology; Medicine; Internal medicine; Longitudinal study; Neuroscience; Pathology; Psychiatry; Radiology; Anxiety","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003085217,0.0003790751,0.0005763651,0.0001245938,0.0002063111,0.00004236473,0.0002615063,0.0001732809,0.0001352431],"category_scores_gemma":[0.0001218134,0.0002264245,0.0001766084,0.0005970077,0.0001702768,0.00005517337,0.0003103622,0.0005607928,0.000006313159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003450688,"about_ca_system_score_gemma":0.0000425073,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004817744,"about_ca_topic_score_gemma":0.006461315,"domain_scores_codex":[0.9974164,0.000483274,0.0005098325,0.0007152217,0.0003421236,0.0005331867],"domain_scores_gemma":[0.9989296,0.0002190307,0.0001725082,0.0005161655,0.00004488809,0.0001177809],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001323015,0.00268796,0.9638527,0.00003830988,0.0002070052,0.00001388201,0.0006459935,0.00000181655,0.0007612463,0.00008823692,0.0001207577,0.03144979],"study_design_scores_gemma":[0.004574728,0.001095387,0.9748498,0.00007703923,0.0001358858,0.00004377601,0.002874307,0.00004801207,0.00003237407,0.0001889828,0.01584064,0.0002390961],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8710482,0.1209304,0.00003865724,0.00656923,0.0004481369,0.0008330243,0.00004485385,0.0000514542,0.00003612284],"genre_scores_gemma":[0.9977965,0.0006783341,0.0003674643,0.0007125166,0.0001770039,0.00006941609,0.0001343626,0.00003117685,0.00003321626],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1267483,"threshold_uncertainty_score":0.9233323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0300757736983824,"score_gpt":0.2937839748082093,"score_spread":0.263708201109827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}