{"id":"W3200299117","doi":"10.1038/s41598-021-97739-w","title":"In vivo generation of collagen specific Tregs with AAV8 suppresses autoimmune responses and arthritis in DBA1 mice through IL10 production","year":2021,"lang":"en","type":"article","venue":"Scientific Reports","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Université Laval","keywords":"Immunology; Immune system; Arthritis; Epitope; Autoimmune disease; Medicine; Adeno-associated virus; T cell; Antibody; Biology; Vector (molecular biology); Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003345971,0.0006335033,0.0003505786,0.0004534171,0.0001708671,0.0003517086,0.0002687938,0.0004898004,0.001637663],"category_scores_gemma":[0.0001193157,0.0002255227,0.0003338069,0.0001177807,0.0003345531,0.0001969154,0.0001401986,0.001574346,0.0004355326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001830385,"about_ca_system_score_gemma":0.0003234189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000485793,"about_ca_topic_score_gemma":0.0008396796,"domain_scores_codex":[0.9996928,0.00005161537,0.00003608588,0.00007409641,0.0000701793,0.00007516677],"domain_scores_gemma":[0.9997768,0.00002752962,0.00007519245,0.00002086398,0.00001541585,0.00008425357],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001561881,0.0001554106,0.0001053047,0.00002734089,0.0000037877,0.00003224452,0.00001584144,0.00006043011,0.9983484,0.00009700844,0.00003666894,0.0009614939],"study_design_scores_gemma":[0.0001718519,0.002009971,0.001422381,0.00001355465,0.00002973065,0.0003355246,0.00003480669,0.001478572,0.9918891,0.00009441059,0.002512968,0.000007323176],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886366,0.00107988,0.006670344,0.0002659523,0.0001823726,0.0001009336,0.0004362721,0.0003793052,0.002248414],"genre_scores_gemma":[0.9854106,0.0007567457,0.006892887,0.0001293811,0.00006828472,0.0001374321,0.0004951584,0.00008897535,0.006020615],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001637663,"threshold_uncertainty_score":0.005478561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04007946943582476,"score_gpt":0.3013635040865821,"score_spread":0.2612840346507574,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}