{"id":"W3200375366","doi":"10.1139/cjc-2021-0024","title":"Thioflavin T fluorescence and NMR spectroscopy suggesting a non-G-quadruplex structure for a sodium binding aptamer embedded in DNAzymes","year":2021,"lang":"en","type":"article","venue":"Canadian Journal of Chemistry","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Chemistry; Deoxyribozyme; Aptamer; G-quadruplex; Fluorescence; DNA; Fluorescence spectroscopy; Nuclear magnetic resonance spectroscopy; Proton NMR; Stereochemistry; Crystallography; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000148509,0.0003405415,0.0002167597,0.0002270358,0.0001797704,0.000279905,0.0004299021,0.0007452981,0.001221576],"category_scores_gemma":[0.000426254,0.0002355446,0.0002769936,0.0001441846,0.0004138914,0.0002468252,0.0001503254,0.0004822768,0.0004463101],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002542706,"about_ca_system_score_gemma":0.0002052647,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005944522,"about_ca_topic_score_gemma":0.0006927242,"domain_scores_codex":[0.9998237,0.00001935339,0.00001215733,0.00006957696,0.00004808212,0.00002715635],"domain_scores_gemma":[0.9996562,0.00009192529,0.0001043204,0.00003646726,0.00007012294,0.00004108908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002447853,0.000004377995,0.00014158,0.00002191809,0.00000309364,0.00005575777,0.00001578358,0.00006802407,0.9990782,0.00006381208,0.000008332024,0.0005146076],"study_design_scores_gemma":[0.000005009022,0.0001355179,0.001747058,0.00000319674,0.000006983188,0.0003026151,0.00002426268,0.001407626,0.9955236,0.0001225757,0.0007150986,0.000006544826],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9586296,0.0007954786,0.03757897,0.0001920089,0.00003555846,0.00005436465,0.0002469346,0.0002605785,0.00220659],"genre_scores_gemma":[0.983075,0.0001960511,0.01350685,0.00009123563,0.000004683809,0.00002682645,0.0002113647,0.00002585298,0.002862146],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001221576,"threshold_uncertainty_score":0.004086554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006257613271418032,"score_gpt":0.2498059345929808,"score_spread":0.2435483213215628,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}