{"id":"W3200398062","doi":"10.1139/cjm-2021-0110","title":"A naturally occurring point mutation in the hyaluronidase gene (<i>hysA1</i>) of <i>Staphylococcus aureus</i> UAMS-1 results in reduced enzymatic activity","year":2021,"lang":"en","type":"article","venue":"Canadian Journal of Microbiology","topic":"Antimicrobial Resistance in Staphylococcus","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; U.S. Food and Drug Administration; National Institutes of Health","keywords":"Staphylococcus aureus; Biology; Hyaluronidase; Microbiology; Biochemistry; Plasmid; Enzyme; Bacteria; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001734197,0.0006077468,0.0004021111,0.0002426813,0.0001613588,0.0002364765,0.0004201643,0.0004465266,0.001933116],"category_scores_gemma":[0.0003812614,0.0001963728,0.0005951024,0.0003290106,0.0003408819,0.0001389176,0.0003274791,0.0006382071,0.0007286665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003488782,"about_ca_system_score_gemma":0.0003286889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009289808,"about_ca_topic_score_gemma":0.0009356955,"domain_scores_codex":[0.9996904,0.00007276668,0.00004795898,0.00005387846,0.00009516095,0.00003979095],"domain_scores_gemma":[0.9997013,0.0000941444,0.0001038317,0.00003624129,0.00002168076,0.0000428309],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001466805,0.0000597206,0.0003580409,0.00006935888,0.00001718776,0.0003601225,0.00002873498,0.0001388879,0.9963051,0.0001661314,0.0001190105,0.002230954],"study_design_scores_gemma":[0.00004499095,0.0004358882,0.008255128,0.0000353746,0.00005780633,0.001965131,0.00007216571,0.002368108,0.9819771,0.00008369229,0.004682213,0.00002244489],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876052,0.0006200763,0.007578646,0.0001382854,0.0001212652,0.0001172253,0.001812885,0.0002514473,0.001754904],"genre_scores_gemma":[0.9888893,0.0003264354,0.007244485,0.00007125419,0.00001488439,0.00007143176,0.001636083,0.0001080738,0.00163805],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001933116,"threshold_uncertainty_score":0.006466985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01354739466845475,"score_gpt":0.2533050446296945,"score_spread":0.2397576499612397,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}