{"id":"W3200435777","doi":"10.3389/fimmu.2021.740330","title":"Increased Monocyte-Derived CD11b+ Macrophage Subpopulations Following Cigarette Smoke Exposure Are Associated With Impaired Bleomycin-Induced Tissue Remodelling","year":2021,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University Medical Centre; St. Joseph’s Healthcare Hamilton; McMaster University","funders":"Janssen Pharmaceuticals; Canadian Institutes of Health Research; Lung Health Foundation; Canadian Pulmonary Fibrosis Foundation; Canadian Lung Association; McMaster University; Pulmonary Fibrosis Foundation","keywords":"Macrophage; Bleomycin; Alveolar macrophage; Integrin alpha M; Lung; Immunology; Monocyte; In vivo; Inflammation; Medicine; Chemistry; Pathology; Flow cytometry; Biology; Internal medicine; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002363214,0.000437844,0.0003501088,0.0005739385,0.0001813947,0.0003902711,0.0001843314,0.0005427662,0.00155829],"category_scores_gemma":[0.0001431651,0.0002434387,0.0003112903,0.0002323727,0.000401173,0.0002098361,0.0002273009,0.0009892696,0.0003332232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001995394,"about_ca_system_score_gemma":0.0001475548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004769812,"about_ca_topic_score_gemma":0.0006678874,"domain_scores_codex":[0.9997429,0.00004071849,0.00003015429,0.00005855137,0.00006430787,0.00006328202],"domain_scores_gemma":[0.9996475,0.00004604141,0.0001415131,0.00003281747,0.00003084078,0.000101178],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002960277,0.00003280096,0.001255511,0.00003162456,0.000004629205,0.00004492468,0.00001251241,0.00001826516,0.9978676,0.00001436506,0.000007686197,0.0004139668],"study_design_scores_gemma":[0.00002478946,0.001152473,0.08271436,0.00001877372,0.00004319139,0.000689559,0.00007248734,0.0004277099,0.9140743,0.00005744933,0.0007163147,0.000008699664],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956614,0.001629384,0.001666772,0.00005566329,0.00001557549,0.0000641883,0.0003982548,0.00006381317,0.0004450024],"genre_scores_gemma":[0.9950466,0.001089742,0.00156319,0.00007343348,0.00001284533,0.0001380046,0.000536916,0.00001894044,0.001520378],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00155829,"threshold_uncertainty_score":0.005213022,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01628750717217061,"score_gpt":0.2324598483909713,"score_spread":0.2161723412188007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}