{"id":"W3200475404","doi":"10.3389/fonc.2021.756001","title":"Melanoma Plasticity: Promoter of Metastasis and Resistance to Therapy","year":2021,"lang":"en","type":"review","venue":"Frontiers in Oncology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Melanoma; Phenotype; Metastasis; Targeted therapy; Medicine; Cancer research; Immunotherapy; Cancer; Acquired resistance; Metastatic melanoma; Phenotypic plasticity; Immunology; Biology; Gene; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002824684,0.0006003117,0.0008126577,0.001373051,0.0002067506,0.0009225831,0.000528253,0.0008800107,0.004302138],"category_scores_gemma":[0.0004173317,0.0002060903,0.0003213354,0.001040801,0.0003390158,0.0008224902,0.0005803148,0.001499516,0.002705398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005880265,"about_ca_system_score_gemma":0.0007708839,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005843468,"about_ca_topic_score_gemma":0.001115249,"domain_scores_codex":[0.9998953,0.00002047647,0.00001147761,0.00001961399,0.00003909701,0.00001406347],"domain_scores_gemma":[0.9998763,0.00004790001,0.00001910959,0.000004291996,0.00003698705,0.00001555796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001011018,0.00005280005,0.0001603074,0.01461016,0.00006655871,0.0002524361,0.00005400621,0.0003391006,0.004070344,0.007868427,0.04161503,0.9308098],"study_design_scores_gemma":[0.00001473368,0.00006427852,0.0005750988,0.001933839,0.00005431481,0.001269017,0.00003179967,0.00007310007,0.0008678481,0.002080644,0.9930221,0.00001318862],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001514655,0.9970868,0.0001851966,0.0003944107,0.0002659329,0.000006082476,0.00003612386,0.00001205222,0.001861888],"genre_scores_gemma":[0.001045564,0.9973524,0.000134687,0.000196372,0.0001437985,0.000008359029,0.0000495787,0.00000230681,0.001067028],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004302138,"threshold_uncertainty_score":0.01439208,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03250405160715081,"score_gpt":0.3179603603004406,"score_spread":0.2854563086932898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}