{"id":"W3200480347","doi":"10.1158/2643-3230.bcd-20-0208","title":"NOT-Gated CD93 CAR T Cells Effectively Target AML with Minimized Endothelial Cross-Reactivity","year":2021,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; University of British Columbia","funders":"National Cancer Institute; National Institutes of Health; Parker Institute for Cancer Immunotherapy; Entertainment Industry Foundation; Cancer Research Institute; Burroughs Wellcome Fund; Stanford Maternal and Child Health Research Institute; American Association for Cancer Research","keywords":"Haematopoiesis; Progenitor cell; Proinflammatory cytokine; Cancer research; CD34; Endothelial stem cell; Stem cell; Bone marrow; Myeloid; Immunology; Biology; In vitro; Cell biology; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001770184,0.0003104572,0.0003228078,0.0001345262,0.0001787366,0.0006536199,0.0003252637,0.0005224058,0.001879438],"category_scores_gemma":[0.0001668299,0.0001172646,0.0001452008,0.0001684429,0.0003671122,0.0002917698,0.0002927023,0.001234118,0.0006309156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004658173,"about_ca_system_score_gemma":0.0002897926,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004016535,"about_ca_topic_score_gemma":0.0008748689,"domain_scores_codex":[0.9997516,0.00003649704,0.00001120245,0.00005620862,0.00009832488,0.00004616664],"domain_scores_gemma":[0.9999303,0.0000162423,0.00001337495,0.000007877068,0.00001801668,0.00001428901],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002414047,0.00006279108,0.0001236407,0.00007962579,0.00001024849,0.0001224057,0.00002107611,0.0005985804,0.9796748,0.002187705,0.003804065,0.01307374],"study_design_scores_gemma":[0.00004389708,0.0003272962,0.0006271623,0.000009807531,0.00002738693,0.0002550231,0.00002528548,0.001900604,0.9554324,0.0007594996,0.04058047,0.0000112041],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8197097,0.0273635,0.1043997,0.01023284,0.002464571,0.0004650907,0.002093882,0.002024947,0.03124576],"genre_scores_gemma":[0.9487843,0.009594048,0.01388712,0.00260328,0.0003306145,0.0001489051,0.0007482941,0.0001909918,0.0237125],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001879438,"threshold_uncertainty_score":0.006287277,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01625178464506925,"score_gpt":0.3011283694173624,"score_spread":0.2848765847722931,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}