{"id":"W3200480347","doi":"10.1158/2643-3230.bcd-20-0208","title":"NOT-Gated CD93 CAR T Cells Effectively Target AML with Minimized Endothelial Cross-Reactivity","year":2021,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; University of British Columbia","funders":"National Cancer Institute; National Institutes of Health; Parker Institute for Cancer Immunotherapy; Entertainment Industry Foundation; Cancer Research Institute; Burroughs Wellcome Fund; Stanford Maternal and Child Health Research Institute; American Association for Cancer Research","keywords":"Haematopoiesis; Progenitor cell; Proinflammatory cytokine; Cancer research; CD34; Endothelial stem cell; Stem cell; Bone marrow; Myeloid; Immunology; Biology; In vitro; Cell biology; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000291902,0.0003874824,0.0007917842,0.0001108761,0.0001367495,0.0002040185,0.0001725712,0.0001750529,0.002394393],"category_scores_gemma":[0.00009131437,0.0003145029,0.0002883484,0.000474054,0.0002838625,0.000395641,0.0001191364,0.0005820015,0.00004247959],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002982209,"about_ca_system_score_gemma":0.001707575,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001528738,"about_ca_topic_score_gemma":0.0003577798,"domain_scores_codex":[0.9970044,0.000233473,0.0003002835,0.0008452015,0.0008964175,0.0007201743],"domain_scores_gemma":[0.998219,0.0003293617,0.0001297841,0.0007128783,0.0003329031,0.0002761023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008557337,0.0008173629,0.02257544,0.0002446989,0.0009929335,0.0009392687,0.0002878716,0.000105978,0.962678,0.00001150239,0.000405681,0.002383939],"study_design_scores_gemma":[0.01543075,0.0005501407,0.01878537,0.0002118353,0.0003919329,0.0001165124,0.00006402778,0.00007699644,0.9523959,0.00001564677,0.01159977,0.0003611729],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926218,0.0007967956,0.0002065579,0.000416755,0.0004446402,0.0009068228,0.0006349438,0.000101586,0.003870047],"genre_scores_gemma":[0.9632506,0.000440913,0.0004809038,0.0005854089,0.0007835646,0.0002215332,0.00009433526,0.0001215949,0.03402109],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03015105,"threshold_uncertainty_score":0.9999307,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01625178464506925,"score_gpt":0.3011283694173624,"score_spread":0.2848765847722931,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}