{"id":"W3200499017","doi":"10.1016/j.parkreldis.2021.09.008","title":"Tau and MAPT genetics in tauopathies and synucleinopathies","year":2021,"lang":"en","type":"review","venue":"Parkinsonism & Related Disorders","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University","funders":"National Institute of Neurological Disorders and Stroke","keywords":"Synucleinopathies; Tauopathy; Frontotemporal dementia; Tau protein; Progressive supranuclear palsy; Neuroscience; Pathological; Dementia; Disease; Biology; Alzheimer's disease; Alpha-synuclein; Parkinson's disease; Medicine; Pathology; Neurodegeneration","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002353742,0.0006087629,0.001845449,0.0004592066,0.0001498653,0.00008967357,0.0001049117,0.0005695482,0.00007085894],"category_scores_gemma":[0.0001220708,0.0005115579,0.0002790702,0.000525363,0.0004110534,0.00007284348,0.0002129038,0.0008210178,0.00005170565],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009508989,"about_ca_system_score_gemma":0.000506494,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009415379,"about_ca_topic_score_gemma":0.00003998374,"domain_scores_codex":[0.9972299,0.0003204611,0.0006394991,0.0008201805,0.0003901772,0.000599766],"domain_scores_gemma":[0.9986674,0.0002079308,0.0001829138,0.0004453306,0.00004875119,0.0004476276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001926393,0.0002922065,0.001011058,0.005496075,0.003981218,0.0008125331,0.0002340555,3e-7,9.995637e-8,0.00009396046,0.0001179459,0.9879413],"study_design_scores_gemma":[0.001832167,0.0002567799,0.0004040831,0.01087591,0.004024714,0.0003560795,0.0002637801,0.00003055896,6.21446e-7,0.0003977652,0.9810527,0.0005048325],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002010475,0.9953281,0.000001023056,0.0001400561,0.00008270819,0.001194435,0.00005812484,0.0000629585,0.001122114],"genre_scores_gemma":[0.004979918,0.9941457,0.0001323348,0.00003239829,0.00002587574,0.0001807186,0.0002774019,0.000112309,0.0001133415],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9874365,"threshold_uncertainty_score":0.9997336,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02482707119559057,"score_gpt":0.3210791572207835,"score_spread":0.2962520860251929,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}