{"id":"W3200549360","doi":"10.1101/2021.09.15.460490","title":"MICAL1 activation by PAK1 mediates actin filament disassembly","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Metropolitan University","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Cell biology; Biology; Actin cytoskeleton; CDC42; Actin; Phosphorylation; Actin remodeling; GTPase; PAK1; Lamellipodium; RHOA; MDia1; Cytoskeleton; Signal transduction; Biochemistry; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008022169,0.0003713619,0.000126245,0.0001534166,0.000235495,0.0002820168,0.0001656109,0.0001775337,0.001852351],"category_scores_gemma":[0.00009163623,0.0001048855,0.0002404101,0.0001070672,0.0001580656,0.0002239508,0.0002932663,0.0005974211,0.0009334201],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002928961,"about_ca_system_score_gemma":0.0001273594,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002846148,"about_ca_topic_score_gemma":0.0003665553,"domain_scores_codex":[0.9998873,0.00001439933,0.000006282034,0.0000200364,0.00002669573,0.00004524518],"domain_scores_gemma":[0.9999216,0.0000107107,0.00002182612,0.000008960429,0.000008565542,0.00002838736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000122784,0.00002207939,0.0002275565,0.00006460329,0.000003918648,0.0001102812,0.00001278992,0.00006509446,0.9981253,0.0002690546,0.00007278313,0.0009036773],"study_design_scores_gemma":[0.00001793126,0.000115598,0.007775473,0.000008500927,0.000008930263,0.000575921,0.00003228956,0.001903933,0.9854617,0.0001464245,0.003949099,0.000004103102],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926018,0.001783141,0.002059154,0.0001758394,0.00002977024,0.00001720326,0.000308443,0.00005437934,0.002970119],"genre_scores_gemma":[0.9961944,0.0005609784,0.0006453769,0.000038427,0.00001137245,0.00001917986,0.0006367824,0.000008569442,0.001884856],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001852351,"threshold_uncertainty_score":0.006196797,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007827182107998907,"score_gpt":0.2049749835726568,"score_spread":0.1971478014646579,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}