{"id":"W3200560872","doi":"10.3389/fphar.2021.612659","title":"Novel Methods and Approaches for Safety Evaluation of Nanoparticle Formulations: A Focus Towards In Vitro Models and Adverse Outcome Pathways","year":2021,"lang":"en","type":"review","venue":"Frontiers in Pharmacology","topic":"Nanoparticles: synthesis and applications","field":"Materials Science","cited_by":134,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Science and Engineering Research Board; Department of Science and Technology, Ministry of Science and Technology, India; Department of Biotechnology, Ministry of Science and Technology, India","keywords":"Nanotoxicology; Nanomedicine; Risk analysis (engineering); Nanotechnology; Biochemical engineering; Computer science; Medicine; Nanoparticle; Materials science; Engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005733157,0.001794225,0.001555771,0.003135565,0.0006784875,0.001995375,0.001596884,0.002005448,0.001696392],"category_scores_gemma":[0.003445387,0.0007559922,0.001715038,0.001561306,0.001570513,0.002405899,0.001694592,0.003470831,0.0010247],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001549585,"about_ca_system_score_gemma":0.001687263,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001967803,"about_ca_topic_score_gemma":0.00207178,"domain_scores_codex":[0.9951226,0.001715212,0.0003637355,0.0007029045,0.00190742,0.0001880998],"domain_scores_gemma":[0.9968741,0.0008343229,0.0005298314,0.0004291614,0.001220769,0.000111852],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000283243,0.0008075056,0.001979628,0.006097184,0.0001687038,0.0005222163,0.0004862835,0.005100792,0.8211954,0.01131269,0.003106187,0.1489403],"study_design_scores_gemma":[0.00005476479,0.002992043,0.004129103,0.001153046,0.0003937774,0.001811975,0.0005190659,0.01923666,0.8453938,0.01117193,0.1128784,0.0002655593],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"review","genre_scores_codex":[0.04880206,0.2128706,0.7123587,0.00309728,0.00130487,0.002323181,0.001794106,0.0009470157,0.01650231],"genre_scores_gemma":[0.2350105,0.2395966,0.5050855,0.00212651,0.0007377997,0.004649441,0.002612331,0.0003290535,0.009852268],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.005733157,"threshold_uncertainty_score":0.03032023,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2644943371276527,"score_gpt":0.4401847588771843,"score_spread":0.1756904217495315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}