{"id":"W3200574709","doi":"10.1056/nejmoa2103485","title":"Overall Survival Benefit with Tebentafusp in Metastatic Uveal Melanoma","year":2021,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Ocular Oncology and Treatments","field":"Medicine","cited_by":878,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Ipilimumab; Melanoma; Hazard ratio; Pembrolizumab; Internal medicine; Oncology; Dacarbazine; Population; Clinical endpoint; Confidence interval; Gastroenterology; Randomized controlled trial; Surgery; Immunotherapy; Chemotherapy; Cancer; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009068988,0.0004218487,0.0009565942,0.0002223775,0.0001532479,0.0002384273,0.0002060831,0.0004197969,0.002607752],"category_scores_gemma":[0.0009900362,0.0001271245,0.0006750173,0.0001658129,0.000369739,0.0002422488,0.0001988237,0.0007968009,0.0001510997],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003209845,"about_ca_system_score_gemma":0.0003967454,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000336504,"about_ca_topic_score_gemma":0.0008806273,"domain_scores_codex":[0.9997744,0.0001209505,0.00001209035,0.00003093501,0.00002710528,0.00003465182],"domain_scores_gemma":[0.9995942,0.000162598,0.00008205781,0.00001691365,0.00001386265,0.0001303877],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7942528,0.007503625,0.01597708,0.001142749,0.001144649,0.0003644024,0.0001345458,0.003643135,0.02923053,0.0002977191,0.001800332,0.1445085],"study_design_scores_gemma":[0.2770718,0.6181318,0.08984689,0.0001958971,0.001528236,0.0009092626,0.0000832244,0.003444273,0.004765013,0.001001803,0.002988293,0.00003360679],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965453,0.002410009,0.0001481411,0.0001437817,0.00003654544,0.000131473,0.00007214946,0.00001158571,0.0005010962],"genre_scores_gemma":[0.9982672,0.0009414473,0.000162681,0.0001128364,0.00006862121,0.0001219336,0.0001054846,0.000002065134,0.0002178233],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002607752,"threshold_uncertainty_score":0.008723855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02141977749778262,"score_gpt":0.2924754618401543,"score_spread":0.2710556843423717,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}