{"id":"W3200574709","doi":"10.1056/nejmoa2103485","title":"Overall Survival Benefit with Tebentafusp in Metastatic Uveal Melanoma","year":2021,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Ocular Oncology and Treatments","field":"Medicine","cited_by":878,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Ipilimumab; Melanoma; Hazard ratio; Pembrolizumab; Internal medicine; Oncology; Dacarbazine; Population; Clinical endpoint; Confidence interval; Gastroenterology; Randomized controlled trial; Surgery; Immunotherapy; Chemotherapy; Cancer; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000483999,0.0001476108,0.0006860329,0.0001654726,0.00002530029,0.000004428884,0.00005821421,0.00005119436,0.0006328684],"category_scores_gemma":[0.0001802054,0.00008547243,0.00006300844,0.0001918087,0.00006487468,0.00007359308,0.00001384379,0.0003686381,0.00000642298],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008936216,"about_ca_system_score_gemma":0.0004147317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001223549,"about_ca_topic_score_gemma":0.0006664311,"domain_scores_codex":[0.9986885,0.0001017654,0.0004333166,0.0001345153,0.0004426405,0.0001992973],"domain_scores_gemma":[0.9990135,0.0002009763,0.0001930222,0.0001456587,0.0001704636,0.0002764069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00513602,0.0008430143,0.8450084,0.00008333834,0.001316059,0.05697155,0.001359413,0.0000693266,0.001581314,0.0009720494,0.001366082,0.08529347],"study_design_scores_gemma":[0.3480608,0.0121151,0.562277,0.001493636,0.001963024,0.03119292,0.0008159391,0.0000366858,0.001459182,0.002748516,0.03761631,0.0002210033],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9814243,0.002736607,0.0001502828,0.01127179,0.0004179787,0.00009783848,0.000001681281,0.000005602672,0.003893917],"genre_scores_gemma":[0.9943632,0.0003320736,0.001948871,0.0006850814,0.000999884,8.759222e-7,0.00001765194,0.00001530644,0.00163702],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3429247,"threshold_uncertainty_score":0.6929465,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02141977749778262,"score_gpt":0.2924754618401543,"score_spread":0.2710556843423717,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}